广西医学Issue(7)：918-920,3.DOI:10.11675/j.issn.0253-4304.2014.07.18
一氧化氮联合高频振荡通气治疗新生儿持续肺动脉高压的疗效观察
Effect of Nitric Oxide Combined with High Frequency Oscillation Ventilation in Treatment of Persistent Pulmonary Hypertension of the Newborn
牟静飞 1覃敏 1李燕 1陈传斯1
作者信息
- 1. 广西壮族自治区妇幼保健院，南宁市 530000
- 折叠
摘要
Abstract
Objective To investigate the effect and safety of nitric oxide ( NO) combined with high frequency oscillation ventilation in the treatment of persistent pulmonary hypertension of the newborn ( PPHN) .Methods Thirty-five newborns with PPHN inhaled NO under high frequency oscillation ventilation ,beginning with the NO density of 20 ×10-6 mg/L(20ppm)which decreased to 5 ×10 -6 mg/L when took effect and then lasted for 36 to 72 hours.To test the pH value,pulmonary artery pressure(PAP),mean airway pressure(MAP),PaO2,oxygenation index(OI),transcutaneous SpO2 of anterior and posterior ductus arteriosus ,blood pressure and heart rate before and 1,24,48 hours after inhaling NO as well as the density of nitrogen dioxide ( NO2 ) before and after inhaling NO .Results MAP,PAP OI 1,24,48 hours after inhaling NO decreased in contrast with those before inhaling NO ( P<0 .05 ) , the transcutaneous SpO 2 of anterior and posterior ductus arteriosus ,PaO2 and pH value increased (P<0.05),and there were no significant changes in heart rate and blood pressure(P>0.05).The density of NO2 was normal during treatment.Conclusion NO combined with high frequency oscillation ventilation is significantly effective in the treatment of PPHN with little significant toxic and side-effect.关键词
肺动脉高压/一氧化氮/高频振荡通气/新生儿Key words
Pulmonary hypertension/Nitric oxide/High frequency oscillation ventilation/Newborn分类
医药卫生引用本文复制引用
牟静飞,覃敏,李燕,陈传斯..一氧化氮联合高频振荡通气治疗新生儿持续肺动脉高压的疗效观察[J].广西医学,2014,(7):918-920,3.
