摘要
Abstract
Objective To investigate the curative effect of rosiglitazone combined with insulin pump ( CSⅡ) and the influence on vascular endothelial function in patients with type 2 diabetes mellitus(T2DM).Methods Eighty-four patients with T2DM were randomly divided into observation group and control group ,with 42 cases in each group .The patients in the control group were treated with CSⅡ,while the patients in the observation group were treated with rosiglitazone combined with CSⅡ.The treatment lasted for 2 weeks.The curative effect ,changes in vascular endothelium-dependent relaxing function(EDD),time of blood glucose control in target,dosage of insulin,and adverse reactions occurring were observed in both groups.Results Fasting blood glucose(FBG),postprandial 2 hours blood glucose(2hPG),total cholesterol(TC),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR) in two groups after treatment were significantly lower than those before treatment ( all P <0 .05 ) , while insulin sensitivity index ( ISI ) after treatment increased significantly ( P<0 .05 ) .No significant difference was observed in body mass index ( BMI ) , triglyceride ( TG ) , high-density lipoprotein(HDL),low-density lipoprotein(LDL) before and after treatment(P>0.05).After treatment,TC,HbA1c and HOMA-IR in the observation group were significantly lower than those in the control group (all P<0.05).EDD in two groups after treatment was significantly higher than that before treatment (P<0.05),and EDD in the observation group was significantly higher than that in the control group after treatment ( P<0 .05 ) .The time of blood glucose control in target and insulin dosage in the observation group were significantly lower than those in the control group (P<0.05),there was no significant difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion Rosiglitazone combined with insulin pump can relieve insulin resistance more effectively in patients with T2DM and improve the function of vascular endothelial .The adverse reactions are few .关键词
2型糖尿病/罗格列酮/胰岛素/输注泵/血管内皮功能Key words
Type 2 diabetes mellitus/Rosiglitazone/Insulin/Infusion pump/Vascular endothelial function分类
医药卫生
