广西医学Issue(8)：1113-1116,4.DOI:10.11675/j.issn.0253-4304.2014.08.29
汉防己甲素对大鼠早期实验性矽肺的治疗效果观察
Efficacy of Sinomenine on Rats with Early Stage Experimental Silicosis
摘要
Abstract
Objective To evaluate the efficacy of sinomenine on rats with early stage experimental silicosis . Methods Ninety healthy adult rats were randomly divided into sinomenine group,positive control group(exposed to dust concurrently),and negative control group ( not exposed to dust ) ,with 30 rats in each group .The animal model of silicosis was prepared by priming quartz into trachea of rats .The treatment began on the fourth day after exposure to dust .The sinomenine group was given sinomenine by gavage .The positive control group and negative control group were given pure water by gavage .The rats were sacrificed when the therapies were over .The lungs of rats were weighed ,hydroxyproline content was measured ,bronchoalveolar lavage fluid cells were counted and classified ,and pathological examination was performed .Results The weights of the rats rose with increasing ages ( P<0.05 ) , while the weigh variations showed different degrees among groups .The weight of sinomenine group was heavier than that of positive control group after exposure to dust(P<0.05).The whole lung dry-wet weight of sinomenine group was lower than that of positive control group (P<0.05).On the 50th day after exposure to dust ,the hydroxyproline content showed no significant difference between sinomenine group and negative control group (P>0.05).However,the hydroxyproline content of positive control group was higher than that of negative control group (P<0.05).The pathological examination showed that the degree of lung consolidation in the sinomenine group was less than that in the positive control group .Conclusion Sinomenine has a certain improvement on rats with early stage experimental silicosis .关键词
矽肺/汉防己甲素/动物实验/大鼠Key words
Silicosis/Sinomenine/Animal experiment/Rat分类
医药卫生引用本文复制引用
郑艳艳,潘瑞辉,梁丹玉,谢晶,甘永金,梁恒秋,凌健安,麦志丹..汉防己甲素对大鼠早期实验性矽肺的治疗效果观察[J].广西医学,2014,(8):1113-1116,4.基金项目
广西科学研究与技术开发计划项目 （）
