广西医学Issue(9)：1249-1252,4.DOI:10.11675/j.issn.0253-4304.2014.09.19
基质金属蛋白酶-9及其抑制剂与老年高血压颈动脉粥样硬化的关系
Relationship of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinase 1 with Hypertensive Carotid Atherosclerosis in Elderly Patients
覃兴航1
作者信息
- 1. 广西壮族自治区南溪山医院内一科，桂林市 541002
- 折叠
摘要
Abstract
Objective To investigate the relationship of matrix metalloproteinase 9(MMP-9) and tissue inhibitor of metalloproteinase 1( TIMP-1) with hypertensive carotid atherosclerosis and its stability .Methods The intima-media thickness(IMT) was measured by using color Doppler ultrasound in 125 cases of hypertension .These patients were divided into simple hypertensive group(n=45),mild atherosclerosis group(n=42) and severe atherosclerosis group(n=38) according to the results of the ultrasound diagnosis.Based on the stability of plaque in atherosclerosis patients,they were classified into stable plaque group(n=45) and unstable plaque group(n=35).Fifty healthy cases without atherosclerosis were selected as control group.The levels of serum MMP-9,TIMP-1 and high-sensitivity C-reactive protein ( hs-CRP) were detected with automatic biochemical analyzer .Results The levels of MMP-9 and hs-CRP increased significantly while the level of TIMP-1 decreased remarkably in the simple hypertension group compared with the controls ( all P <0 .05 ) .The levels of MMP -9 and hs-CRP were significant higher while the level of TIMP-1 was significantly lower in the severe atherosclerosis group in contrast with those in the simple hypertension group and mild atherosclerosis group (P<0.05). The levels of MMP-9 and hs-CRP increased significantly ,but the levels of TIMP-1 decreased significantly in the unstable plaque group compared with stable plaque group (P<0.05).Multivariate logistic regression analysis showed that IMT , MMP-9,TIMP-1 were the independent risk factors for hypertensive carotid atherosclerosis .Conclusion The levels of serum MMP-9 and TIMP-1 closely correlate with the formation and stability of hypertensive carotid plaque .关键词
高血压/颈动脉粥样硬化/基质金属蛋白酶-9/基质金属蛋白酶-9抑制剂/颈动脉斑块Key words
Hypertension/Carotid atherosclerosis/Matrix metalloproteinase-9/Tissue inhibitor of metalloproteinase/Carotid plaque分类
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覃兴航..基质金属蛋白酶-9及其抑制剂与老年高血压颈动脉粥样硬化的关系[J].广西医学,2014,(9):1249-1252,4.
