广西医学Issue(10)：1424-1427,4.DOI:10.11675/j.issn.0253-4304.2014.10.21
剑麻皂素对大鼠局灶性脑缺血再灌注损伤的保护作用及其机制
Protective Effect of Tigogenine on Rats with Focal Cerebral Ischemia-Reperfusion Injury and Its Mechanism
摘要
Abstract
Objective To explore the protective effects of tigogenine on rats with focal cerebral ischemia-reperfusion injury and its mechanism.Methods Copied the model of focal cerebral ischemia reperfusion in rats by middle cerebral artery occlusion(MCAO).Then 60 rats were randomly divided into model group ,Sanqitongshu group,high-,middle-and low-dose tigogenine groups,with 12 rats in each group.The model group was given distilled water by gavage,Sanqitongshu group was given Sanqitongshu capsule by gavage,high-,middle-and low-dose tigogenine groups were given tigogenine of 450 mg/(kg・ d),225 mg/(kg・ d)and 113 mg/(kg・ d),respectively,by gavage.The neuroethology score,volume of cerebral infarction,cerebral water content and the serum superoxide dismutase (SOD),malonaldehyde(MDA),glutathione peroxidase (GSH-Px),lactic acid(LA) levels were compared among groups.Results The neuroethology score of high-and middle-dose tigogenine groups was significantly lower than that of model group(P <0.05),the absolute and relative volumes of ischemia of high-and middle-dose tigogenine groups were significantly smaller than those of model group(P <0.05),the cerebral water content of high-dose tigogenine group was significantly lower than that of model group(P <0.05).The serum SOD and GSH-Px levels of high-dose tigogenine group were significantly higher than those of model group while the MDA and LA levels were significantly lower than those of model group (P <0.05).The serum SOD level of middle-dose tigogenine group was significantly higher than that of model group (P <0.05),but the MDA level was lower than that of model group (P <0.05).Conclusion Tigogenine has the protective effect on rats with focal cerebral ischemia -reperfusion injury, which might be related with anti-free radical,anti-oxidation function and relieving lactic acidosis .关键词
缺血再灌注损伤/剑麻皂素/局灶性脑缺血/大鼠Key words
Ischemia-reperfusion injury/Tigogenine/Focal cerebral ischemia/Rat分类
医药卫生引用本文复制引用
赖克道,李燕婧,钟正贤,陈学芬..剑麻皂素对大鼠局灶性脑缺血再灌注损伤的保护作用及其机制[J].广西医学,2014,(10):1424-1427,4.基金项目
广西自然科学基金资助项目 （）
