广西医学Issue(4)：470-472,3.DOI:10.11675/j.issn.0253-4304.2015.04.11
胰岛素样生长因子-1和转化生长因子-β1在宫腔粘连患者子宫内膜表达的研究
Expression of insulin-like growth factor-1 and transforming growth factor-β1 in intrauterine adhesion endometrium
摘要
Abstract
Objective To explore the effect of insulin-like growth factor-1 ( IGF-1 ) and transforming growth factor-β1 ( TGF-β1 ) on intrauterine adhesion(IUA).Methods Forty-five patients with IUA(mild 15,moderate 15,severe 15) were detected for the expression levels of IGF-1 and TGF-β1 in the normal endometrium and adhesion tissues by immunohistochemistry.Results The expressions of IGF-1 and TGF-β1 were observed in the normal endometrium and adhesion tissues,which were significantly lower in the normal endometrium than in the adhesion tissues among mild,moderate and severe adhesion groups(P<0.05).The more severe IUA was,the higher expression levels of IGF-1 and TGF-β1 in adhesion tissues were,and the highest expression levels were in the severe adhesion group while the lowest were in the mild adhesion group(P<0.05).The IGF-1 expression positively correlated with the TGF-β1 expression in the adhesion tissues (r=0.53,P<0.01).Conclusion The expressions of IGF-1 and of TGF-β1 in the adhesion tissues increase with the increasing severity of IUA,which suggests IGF-1 and TGF-β1 might involve in the development of IUA.关键词
胰岛素样生长因子-1/转化生长因子β1/宫腔粘连/免疫组织化学Key words
Insulin-like growth factor-1/Transforming growth factor-β1/Intrauterine adhesion/Immunohistochemistry分类
医药卫生引用本文复制引用
曾薇薇,姚吉龙,李军..胰岛素样生长因子-1和转化生长因子-β1在宫腔粘连患者子宫内膜表达的研究[J].广西医学,2015,(4):470-472,3.基金项目
广东省深圳市医疗卫生类科研项目 （）
