广西医学Issue(4)：479-481,3.DOI:10.11675/j.issn.0253-4304.2015.04.14
慢性阻塞性肺疾病患者外周血T淋巴细胞的表达及其与肺功能的关系
Expression of peripheral blood T lymphocytes and its relationship with lung function among patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the expression of peripheral blood T lymphocytes and its relationship with lung function among patients with chronic obstructive pulmonary disease(COPD).Methods The levels of CD3+,CD4+,CD8+and CD4+/CD8+T lymphocytes were detected among 60 patients with stable COPD(stable COPD group),60 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD,AECOPD group) and 60 normal controls.Lung function test was performed in the stable COPD group before treatment. Results The serum levels of CD3+,CD4+and CD4+/CD8+T lymphocytes were lower while the level of CD8+T lymphocytes was higher in the AECOPD group and stable COPD group compared with the controls(P<0.01).The serum levels of CD3+,CD4+and CD4+/CD8 +T lymphocytes were higher while the level of CD8 +T lymphocytes was lower in the stable COPD group compared with AECOPD group (P<0.05).In the stable COPD group,the level of CD4 +T lymphocytes positively correlated with forced expiratory volume in one second (FEV1) and forced vital capacity(FVC) significantly(P<0.01),the level of CD4 +/CD8 +T lymphocytes positively correlated with FEV1 and FVC(P<0.05),the level of CD8 +T lymphocytes negatively correlated with FEV1 and FVC(P<0.05),and the level of CD3 +T lymphocytes showed no correlation with FEV1 and FVC( P>0.05) .Conclusion Cellular immune dysfunction can be observed in COPD patients,which presents a progressive loss of immune function with the increasing severity of the disease and poorer lung function.关键词
慢性阻塞性肺疾病/T淋巴细胞/肺功能Key words
Chronic obstructive pulmonary disease/T lymphocyte/Lung function分类
医药卫生引用本文复制引用
邵有和,陈昌枝,覃淑娟,吴文彬,覃家盟..慢性阻塞性肺疾病患者外周血T淋巴细胞的表达及其与肺功能的关系[J].广西医学,2015,(4):479-481,3.基金项目
广西贵港市科学研究与技术开发计划项目 （）
