广西医学Issue(5)：596-598,622,4.DOI:10.11675/j.issn.0253-4304.2015.05.04
广西扶绥县壮族人群CXCL12基因多态性与肝癌家系遗传易感性的关系
Relationship between CXCL12 polymorphism and genetic susceptibility of hepatocellular carcinoma family of Zhuang population in Fusui County,Guangxi
摘要
Abstract
Objective To investigate the relationship between CXCL12 rs3780891 polymorphism and genetic susceptibility to hepatocellular carcinoma( HCC) in Zhuang population in Fusui County,Guangxi.Methods The control study involved 79 members from HCC family(HCC family group,20 HCC cases,59 immediate family members) and 40 members from normal family(normal control group) in Fusui County, Guangxi.Mass spectrometry was used to determine the genotype frequency of CXCL12 rs3780891 polymorphism.A non-conditional logistic regression analysis on the relationship between different genotypes and the risks of HCC polymorphism was performed.Results The CXCL12 rs3780891 locus owned three genotypes of AA,GA and GG.There was no significant difference in the frequency of GA genotype between normal control group and HCC patients in HCC family group( P>0.05).There was no significant difference in the frequency of GA genotype between HCC patients and their family members in the HCC family group(P>0.05).Conclusion CXCL12 rs3780891 polymorphism doesn′t correlate with genetic susceptibility to HCC family clustering in Fusui County,Guangxi.关键词
肝细胞癌/CXCL12基因/单核苷酸多态性/家族聚集性/遗传易感/广西Key words
Hepatocellular carcinoma/CXCL12 gene/Single nucleotide polymorphism/Family clustering/Genetic susceptibility/Guangxi分类
医药卫生引用本文复制引用
何承诚,谢裕安,毛赛南,赵瑞强,闫雷,黄正..广西扶绥县壮族人群CXCL12基因多态性与肝癌家系遗传易感性的关系[J].广西医学,2015,(5):596-598,622,4.基金项目
国家自然科学基金（81260320）；广西研究生教育创新计划 （）
