广西医学Issue(5)：628-630,3.DOI:10.11675/j.issn.0253-4304.2015.05.14
糖尿病肾病危险因素及血压控制临界值分析
Risk factors for diabetic nephropathy and threshold of blood pressure control
摘要
Abstract
Objective To explore the risk factors for diabetic nephropathy(DN) and the threshold of blood pressure(BP) control. Methods Fifty-five cases of type 2 diabetes mellitus( T2DM group) and 63 cases of DN ( DN group) were enrolled in the study.The clinical characteristics,including gender,age,duration of diabetes,body mass index(BMI),blood pressure (systolic blood pressure(SBP), diastolic blood pressure(DBP)),fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPBG),hemoglobin A1c(HbA1c) and 24-hour urine protein quantitation(24hUPQ),were compared between two groups.The risk factors for DN were analyzed.Results The result of univariate analysis revealed that the patients in DN group were older, and owned longer duration of diabetes, higher SBP and 24hUPQ compared with T2DM group(P<0.05);SBP positively correlated with 24hUPQ(P=0.036).The result of multivariate logistic unconditional regression analysis showed that high SBP was the independent risk factor for DN(P<0.05),the area under ROC curve of SBP for DN diagnosis was 0.652,and the thresholds of SBP and DBP were 136 mmHg and 82 mmHg,respectively.Conclusion High SBP is the risk factor for DN.Blood pressure should be controlled within 140/80 mmHg among patients with T2DM in order to reduce the risks of DN or delay the progression.关键词
糖尿病/糖尿病肾病/高血压Key words
Diabetes mellitus/Diabetic nephropathy/Hypertension分类
医药卫生引用本文复制引用
刘春斌,吴潇芸,张丽娣,杨望荣..糖尿病肾病危险因素及血压控制临界值分析[J].广西医学,2015,(5):628-630,3.基金项目
广西高校科学技术研究项目 （）
