广州医药Issue(5)：10-14,5.DOI:10.3969/j.issn.1000-8535.2014.05.004
参附注射液对兔供心的保护作用
Cardioprotective effects of Shenfu Injection (SFI)added to Stanford Solution (STF)prior to heart arrest and during the cold heart preservation:an in vitro rabbit heart study
摘要
Abstract
Objective Previous studies have demonstrated that Shenfu injection (SFI)could protect donor heart against post-ischemia injury when applied immediately after reperfusion,but its potential cardioprotective effect added to Stanford Solu-tion (STF)prior to heart arrest and during the cold heart preservation is unknown. Methods Sixteen rabbits were anesthe-tized.Hearts were harvested and subjected to Langendorff perfusion.After equilibrium,hearts were arrested with a cold Stanford solution (STF),followed by 4 hours of cold statistic preservation in STF,and 90 min reperfusion subsequently.SFI (60ml/L) were added to STF solution separately in above mentioned periods in experiment group (SFI-STF,n =8),where saline vehicle were added to STF in control group (Vehicle-STF,n =8). Results Myocardial water content and infarct size were significant-ly decreased in SFI-STF as compared with Vehicle-STF (P <0.05).Cardiac function in SFI-STF hearts returned to satisfactory level shortly after the initiation of reperfusion and still better preserved throughout the reperfusion;however,vehicle-STF hearts showed persistent hypokinesia during the peri-reperfusion period. Conclusion The addition of SFI (60ml/L)to the STF in-duced an improvement in functional recovery,alleviate ischemia-reperfusion induced myocardial injury,and afford cardioprotec-tive role for donor hearts protection.关键词
参附注射液/兔/供心/保护/保存Key words
SFI/Rabbit/Donor heart/Preservation引用本文复制引用
陈伟民,许少丹,陈敏东,陈文广,黄达德..参附注射液对兔供心的保护作用[J].广州医药,2014,(5):10-14,5.基金项目
广州市卫生局中西医结合项目 （）
