解放军医药杂志Issue(5)：19-21,26,4.DOI:10.3969/j.issn.2095-140X.2014.05.005
姜黄素对胶质瘤U87细胞增殖和迁移能力的影响
Effects of Curcumin on Cell Proliferation and Migration Ability of Glioma U87 Cells
曹一波 1于君 1马晶 1金晨 1马亚辉 1金纬 1丁玉珀 1侯英泊1
作者信息
- 1. 300381 天津，北京军区天津疗养院神经外科
- 折叠
摘要
Abstract
Objective To explore the effects of Curcumin on cell proliferation and migration ability of glioma U87 cells. Methods Survival rates of glioma U87 cells, cultured by normal culture solutions and different concentra-tions (25, 50 and 100μmol/L) Curcumin solution were detected using CCK-8 assay after culturing for 24 h, 48 h and 72 h;effect of cell migration by 100 μmol/L Curcumin solution was assessed using cell scuffing test; 20 Sprague-Dawley (SD) rats were randomly divided into control group (n=5) and three experiment groups (group A, group B, group C, each n= 5) after establishing glioma models. The 7th d after establishing models, control group was lavaged with saline solution, and group A, B and C was lavaged with 100, 200 and 300 mg/kg Curcumin solution respectively, (1 time/ d) for 14 d. Tumor volumes were measured on the 15th d using microPET-CT method. Results Survival rates of glioma U87 cells were decreased with elevated Curcumin concentration and lengthened cultivation time (P<0. 05);level of U87 cell migration was lower than that in control group after being cultured with Curcumin solution (100μmol/L) for 24 h and 48 h (P<0. 05);tumor volumes in group B and C were smaller than those in group A and control group (P<0. 05). Con-clusion Curcumin may inhibit the cell proliferation and migration in glioma U87 cells.关键词
姜黄素/胶质瘤/增殖/迁移/大鼠,Sprague-DawleyKey words
Curcumin/Glioma/Proliferation/Migration/Rat, Sprague-Dawley分类
医药卫生引用本文复制引用
曹一波,于君,马晶,金晨,马亚辉,金纬,丁玉珀,侯英泊..姜黄素对胶质瘤U87细胞增殖和迁移能力的影响[J].解放军医药杂志,2014,(5):19-21,26,4.
