解放军医药杂志Issue(5)：30-33,4.DOI:10.3969/j.issn.2095-140X.2014.05.008
胃肠道小间质瘤55例临床分析
Clinical Analysis of 55 Patients with Small Intestinal Stromal Tumors
摘要
Abstract
Objective To investigate the clinical features, diagnosis and treatment methods of small gastrointes-tinal stromal tumors ( GISTs) . Methods Clinical data of 55 patients with small GISTs undergoing surgery during Octo-ber 2004 and April 2010 was retrospectively analyzed, and follow-up analysis was performed at the same time. Results Among the 55 small GISTs patients, the percentage of patients with clinical symptoms was 58. 2% and patients with gas-tric tumors were 80. 0% respectively including 52. 7% in upper stomach. The percentage of patients with very low and low grade of Flecture risk classification was 92. 7%, and risk classification of tumor diameter of no more than 1cm was lower, but positive Ki-67 had nothing to do with the risk classification. Minimally invasive tumor resection was performed in 33 cases ( minimally invasive group) including 17 cases of laparoscopic gastric partial resection, 14 cases of endoscop-ic submucosal dissection and 2 cases of laparoscopic combined with endoscopic surgery; open tumor resection was per-formed in 22 cases ( open tumor resection group) including 18 cases of gastric partial resection, 3 cases of proximal gas-trectomy and 1 case of pancreaticoduodenectomy. The differences in bleeding volum and postoperative dieting time be-tween the open surgery group and minimally invasive surgery group were statistically significant (P<0. 01, P<0. 05). A total of 38 patients were followed up for 26-104 months, median time was 41 months, and only one patient had relapse 22 months after endoscopic submucosal dissection. Conclusion Only half of small GIST patients have clinical manifesta-tions, most of the tumors are located in the upper part of the stomach with low risk and recurrent risk, but Ki-67 can not be used as prognostic indicator of small GIST. Minimally invasive surgery is safe and effective.关键词
胃肠道间质肿瘤/疾病特征/诊断/外科手术/随访研究Key words
Gastrointestinal stromal tumor/Disease attribute/Diagnosis/Surgical procedure/Follow-Up study分类
医药卫生引用本文复制引用
尹光,徐文通,沈勇,刘利成,菅锎宇,杨倚天..胃肠道小间质瘤55例临床分析[J].解放军医药杂志,2014,(5):30-33,4.基金项目
全军“十二五”面上项目(CWS11J103) （CWS11J103）
