解放军医药杂志Issue(6)：12-16,5.DOI:10.3969/j.issn.2095-140X.2014.06.004
靶向药物联合介入封堵治疗动脉导管未闭合并艾森门格综合征5例效果观察
Effect Observation of Targeted Drug Combined with Interventional Therapy in Treatment of 5 Patients with Pa-tent Ductus Arteriosus Complicated by Eisenmenger Syndrome
摘要
Abstract
Objective To explore the effect of targeted drugs combined with interventional therapy in treatment of patent ductus arteriosus (PDA) complicated by Eisenmenger syndrome (ES). Methods The value of pulmonary blood flow/ systemic blood flow (Qp/Qs) was 1. 0-1. 5 by right heart catheterization in 5 PDA patients with severe pul-monary arterial hypertension (PAH) during June 2011 and October 2013. The trial plugging and acute pulmonary vasodi-latation tests were performed upon admission, and then patients with positive results underwent interventional therapy. All patients received standard treatment of targeted drug. The indicatio curativa and effect of interventional therapy were com-prehensively evaluated after the treatment for 6 and 12 months. Results There was no death case during 12 months of follow-up. Three patients underwent interventional surgery successfully, and the values of pulmonary artery pressure and pulmonary vascular resistance were decreased; one patient still had no surgical indication after targeted drug for 6 months, but the general condition improved;one patient abandoned the treatment after targeted drug for one month, and his condition gradually worsened. Conclusion Some patients with PDA complicated by ES may benefit from the active targeted drug combined with interventional therapy.关键词
高血压,肺性/动脉导管未闭/介入/心间隔封堵装置Key words
Hypertension, pulmonary/Patent ductus arteriosus/Intervention/Septal occluder device分类
医药卫生引用本文复制引用
卢蓉,张刚成,尚小珂,沈群山,周红梅,刘洋..靶向药物联合介入封堵治疗动脉导管未闭合并艾森门格综合征5例效果观察[J].解放军医药杂志,2014,(6):12-16,5.基金项目
国家十二五科技支撑项目(2011BAI11B15) （2011BAI11B15）
