解放军医药杂志Issue(7)：16-20,5.DOI:10.3969/j.issn.2095-140X.2014.07.005
鞘氨醇激酶-1、C-反应蛋白对急性胰腺炎严重程度的预测价值
Value of Sphingosine Kinase 1 and C-reactive Protein in Prediction of Severity Degree of Acute Pancreatitis
摘要
Abstract
Objective To compare the forecasting value of C-reactive protein (CRP) and Sphingosine Kinase 1 (SphK1) in diagnosis of the severity of the acute pancreatitis (AP). Methods A total of 30 patients with AP during De-cember 2012 and July 2013 were divided into severe acute pancreatitis group (SAP group, n =13) and mild acute pancrea-titis group (MAP group, n =17). Ten healthy volunteers were selected as control group. The levels of serum CRP, SphK1 mRNA and SphK1 enzymatic activity of peripheral blood leucocyte were measured in AP patients at 48 h, 72 h, 5 d and 7 d after the attack of AP. Results At 48 h, 72 h, 5 d and 7 d, the levels of serum CRP, SphK1 mRNA and SphK1 enzy-matic activity of peripheral blood leucocyte in patients with MAP and SAP were elevated, compared with those in control group (P <0. 05); while the difference in serum CRP level was not statistically significant between MAP and SAP groups (P >0. 05). The levels of SphK1 mRNA and SphK1 enzymatic activity of peripheral blood leucocyte in SAP patients were elevated, compared with those in MAP patients at 48 h, 72 h and 5 d (P <0. 05); the differences in level of SphK1 mRNA and SphK1 enzymatic activity of peripheral blood leucocyte were not statistically significant at 7 d between MAP and SAP groups (P >0. 05). The highest sensitivity and diagnostic accuracy of SphK1 were observed at 48 h after the AP attack, and the area under ROC curve was up to 0. 946. Conclusion The value of measurement of SphK1 of peripheral blood leu-cocyte is preferred in the early prognosis of AP, compared with those by CRP.关键词
胰腺炎/鞘氨醇激酶-1/C-反应蛋白Key words
Pancreatitis/Sphingosine kinase 1/C-ractive protein分类
医药卫生引用本文复制引用
杨林,钟明,李永继,郑晓博,闫洪涛,汤礼军,黎冬暄..鞘氨醇激酶-1、C-反应蛋白对急性胰腺炎严重程度的预测价值[J].解放军医药杂志,2014,(7):16-20,5.基金项目
国家自然科学基金(81000185) （81000185）
四川省青年科技创新团队基金项目(2011JTD0010) （2011JTD0010）
