解放军医药杂志Issue(8)：17-20,4.DOI:10.3969/j.issn.2095-140X.2014.08.006
血糖波动对2型糖尿病合并冠心病患者冠状动脉病变的影响
Influence of Blood Sugar Fluctuation on Coronary Artery Lesion in Patients with Type 2 Diabetes Mellitus Com-plicated with Coronary Atherosclerotic Heart Disease
摘要
Abstract
Objective To explore the influence of blood sugar fluctuation on coronary artery lesion in patients with type 2 diabetes mellitus (T2DM) and coronary atherosclerotic heart disease. Methods A total of 43 inpatients with T2DM complicated with coronary artery disease diagnosed by coronary angiography (CAG), from February to September 2013 in Department of Endocrinology underwent 72 h continuous blood sugar monitoring. According to the level of stand-ard deviation of blood glucose (SDBG), the patients were divided into abnormal group (SDBG≥1. 4 mmol/L, n=24) and normal group (SDBG<1. 4 mmol/L, n=19). Indexes of blood sugar fluctuation in the two groups were compared, and the levels of C-reactive protein ( CRP) were also detected and compared, and then CAG results underwent Gensini scoring. The correlation between Gensini score and related indexes was analyzed. Results ①Values of CRP, Gensini score, mean amplitude of glycemic excursions (MAGE), mean postprandial glucose excursion (MPPGE) and absolute means of daily difference (MODD) in abnormal group were significantly higher than those in normal group (P<0. 05);②Values of MAGE, MPPGE, MODD, CRP and systolic blood pressure ( SBP) were significantly positive correlation with Gensini score (r=0. 511, 0. 442, 0. 323, 0. 495, 0. 582, P<0. 05); multielement stepwise regression analysis showed that values of MAGE, CRP and SBP were independently correlated with Gensini score ( Y =0. 443MAGE +0. 397SBP+0. 365CRP-5. 316). Conclusion Blood glucose fluctuations is closely related to coronary artery lesions in T2DM patients with coronary atherosclerotic heart disease, and it is an independent risk factor of coronary artery disease in T2DM patients.关键词
糖尿病,2型/冠心病/血糖波动/冠状动脉疾病/C反应蛋白Key words
Diabetes mellitus, type 2/Coronary disease/Blood sugar fluctuation/Coronary artery disease/C-reactive protein分类
医药卫生引用本文复制引用
陈少敏,吕肖锋,宫倩倩,武晋晓,焦秀敏,王亚双,马艳霞,彭永..血糖波动对2型糖尿病合并冠心病患者冠状动脉病变的影响[J].解放军医药杂志,2014,(8):17-20,4.基金项目
国家科技重大专项子课题(2011ZX09307-001-08) （2011ZX09307-001-08）
