摘要
Abstract
Objective To explore the distribution and drug resistances of the pathogenic bacteria in children with lower respiratory infection in pediatric intensive care unit ( PICU) of department of cardiac surgery, and to provide evidence for clinical anti-infective therapy and reasonable use of antibacterials. Methods A total of 88 children with lower respiratory infection after operation for congenital heart disease during January 2012 and December 2013 in the PICU of the department of cardiac surgery were selected, and sputum samples were taken for cultivation and drug sensitiv-ity test, and then pathogenic bacteria were isolated and analyzed. Results A total of 46 pathogenic microorganisms were isolated from 432 sputum samples in the 88 children, and the isolating rate was 10. 65%, in which 43 strains were gram-negative bacteria, which accounted for 93. 48%;2 strains were gram-positive bacteria, which accounted for 4. 35%;1 was fungus, which accounted for 2. 17%. The resistance rates of the top 5 detected gram-negative bacteria such as kleb-siella pneumoniae and pseudomonas aeruginosa to Ampicillin, Ampicillin/Sulbactam Sodium and Ceftriaxone Sodium were 100. 00%;the resistance rate of pseudomonas aeruginosa to Imipenem was 100. 00%;acinetobacter baumannii was 100. 00% sensitive to Cefoperazone Sodium/Sulbactam Sodium and Ceftriaxone Sodium, but multidrug resistance and pan-drug resistance to other drugs were observed;the resistance rates of escherichia coli to Ampicillin, Piperacillin Sodi-um , Cefuroxime Sodium and Ceftriaxone Sodium were 100. 00%;and the resistance rates of stenotrophomonas maltophilia to Ceftazidime and Ticarcillin Sodium-Clavulanate Potassium were 50. 00%. Conclusion It is of vital significance for postoperative rehabilitation of children with congenital heart disease in PICU of department of cardiac surgery to strengthen postoperative respiratory tract administration, quickly control and monitor the distribution and drug resistances of the path-ogenic bacteria of lower respiratory infection and reasonably select anti-infective agents based on the drug sensitivity test results.关键词
心脏缺损,先天性/重症监护病房,儿科/下呼吸道感染/病原微生物/抗药性,微生物Key words
Heart defects, congenital/Intensive care units, pediatric/Lower respiratory infection/Causative organism/Drug resistance, microbial分类
医药卫生
