解放军医药杂志Issue(10)：78-81,4.DOI:10.3969/j.issn.2095-140X.2014.10.022
乙肝病毒DNA定量水平和乙型肝炎病毒标志物定量检测指标相关性研究
Correlation Research on Quantitative Level of Hepatitis B Virus DNA and Quantitative Detection Index Associat-ed to Hepatitis B Virus Markers
摘要
Abstract
Objective To investigate the correlation between quantitative detection index associated to Hepatitis b virus ( HBV) markers and the quantitative level of HBV DNA. Methods A total of 368 patients with great three posi-tive results and 507 patients with small three positive results were confirmed by using enzyme-linked immunosorbent assay ( ELISA) during January 2013 and June 2014 in infectious diseases department, and 50 patients were randomly selected from the 368 patients as great three positive results group ( group A) , and 50 patients were randomly selected from 507 patients as small three positive results group ( group B) . Blood samples of the two groups underwent quantitative detec-tions of HBV markers and HBV DNA simultaneously. Results HBsAg content and HBV DNA quantitative test results were significantly higher than those in group B (P<0. 01);positive rate of HBV DNA quantitation in group A was signif-icantly higher than that in group B (P<0. 01);HBV DNA content had correlation with the HBsAg and HBeAg contents in great three positive result patients with positive HBV DNA (P<0. 01). Conclusion HBV DNA level has obviously positive correlation with HBsAg and HbeAg levels, and quantitative detections of HBV DNA, HBsAg and HbeAg have important clinical significance for judging HBV infectivity.关键词
乙型肝炎抗体/乙型肝炎抗原/乙型肝炎病毒Key words
Hepatitis B antibodies/Hepatitis B antigens/Hepatitis B virus分类
医药卫生引用本文复制引用
杨勇,王占科,陈鑫,钟莹..乙肝病毒DNA定量水平和乙型肝炎病毒标志物定量检测指标相关性研究[J].解放军医药杂志,2014,(10):78-81,4.基金项目
国家科技支撑项目(2008BAI52B03) （2008BAI52B03）
