解放军医药杂志Issue(3)：20-23,4.DOI:10.3969/j.issn.2095-140X.2015.03.005
医用胶粘剂氰基丙烯酸酯聚合热对神经组织损伤的研究
A Study of Polymerization Heat Induced by Cyanoacrylate in Medical Adhesive on Nerve Tissual Lesions
摘要
Abstract
Objective To study the polymerization heat induced by Cyanoacrylate in medical adhesives on nerve tissual lesions. Methods A total of 80 healthy SD male rats were randomly divided into group A, B, C and D ( n=20 for each group) , and lesion models were established by dropping Cyanoacrylate to freeing left sciatic nerves. Group A was given 20 μl Cyanoacrylate (1 drop);group B was given 80 μl Cyanoacrylate (4 drops);group C was given 20 μl Ethyl Cyanocrylate (1 drop);group D was given 20μl normal saline (1 drop) to left sciatic nerves. The differences of left sci-atic nerves were generally observed after 24 h in the four groups, and sciatic electrophysiology detection, hematoxylin and eosin ( HE) staining and warthin-starry staining were performed, and then the lesions were observed with histological method . Results There were statistically significant differences in sciatic general observation and histological observation between group C and group A, B and D, while the differences in sciatic electrophysiology indexes between group C and group A, B and D were statistically significant (P>0. 01). Conclusion The polymerization heat induced by different dosages of Cyanoacrylate may have mild nerve tissual lesions, so it can be used as adhesive and fixing agents to repair nervous tissues.关键词
组织黏合剂/氰丙烯酸盐类/创伤,神经系统/大鼠, Sprague-DawleyKey words
Tissue adhesives/Cyanoacrylates/Trauma, nervous system/Rats, Sprague-Dawley分类
医药卫生引用本文复制引用
郭占芳,梁向党,蔡宏飞,孙赓,李宏伟,邹秀强..医用胶粘剂氰基丙烯酸酯聚合热对神经组织损伤的研究[J].解放军医药杂志,2015,(3):20-23,4.基金项目
科技部国际合作项目(2014DFA31230) （2014DFA31230）
