解放军医药杂志Issue(3)：24-27,4.DOI:10.3969/j.issn.2095-140X.2015.03.006
医用胶制动对大鼠坐骨神经离断吻合修复效果影响研究
Effect of Medical Adhesive Braking on Severed Sciatic Nerves for Anastomosis in Rats
摘要
Abstract
Objective To observe the effect of medical adhesive braking on severed sciatic nerves for anastomo-sis in rats. Methods A total of 30 male SD rats were selected and models were established, and then the rats were ran-domly divided into experiment group (n=15) and control group (n=15). In experiment group, the sciatic nerves were transected at the midpoint, and then were sutured for anastomosis with traditional method under operating microscope. The silica gel tubes were put over the surfaces of nerve suture sites, and the stomas sites were similar with the axial center of the tubes, and then 20 μl medical adhesive were respectively dripped on two sides of the tubes. In control group, the sciatic nerves were transected at the midpoint, and then were sutured for anastomosis with traditional method under oper-ating microscope only. Nerval connective tissues were given general observation, indexes of nervous functions, electro-physiologic detection and histopathological observation were made in postoperative 8th week, and the hyperplasia condi-tions of intraneural and extraneural connective tissues were recorded, and the number of regenerated nerve fibers in sto-mas were detected. Results In postoperative 8th week, the obvious adhesions were found in nervous and surrounding tis-sues;the values of function indexes of left sciatic nerve (in the 6th and 8th weeks), neural latency, maximum thickness of scar connective tissue in epineurium and the total area of 4 intraneural connective tissues in experiment group were signifi-cantly lower than those in the control group (P<0. 05), while the values of neural amplitude and regenerated number of nerve fibers were higher than those in the control group (P<0. 05). Conclusion The medical adhesive braking on se-vered sciatic nerves for anastomosis in rats may inhibit the hyperplasia of scar connective tissues, and promote the regen-eration of nerve fibers.关键词
氰丙烯酸盐类,制动,修复/坐骨神经/大鼠Key words
Cyanoacrylates/Braking, reconstructive/Sciatic nerve/Rats分类
医药卫生引用本文复制引用
邹秀强,梁向党,郭占芳,孙赓,余宽宽,房卓群..医用胶制动对大鼠坐骨神经离断吻合修复效果影响研究[J].解放军医药杂志,2015,(3):24-27,4.基金项目
科技部国际合作项目(2014DFA31230) （2014DFA31230）
