解放军医药杂志Issue(3)：58-62,5.DOI:10.3969/j.issn.2095-140X.2015.03.014
不同途径输注DC-CIK联合TACE治疗进展期肝癌的临床研究
A Clinical Study of Different Approaches of DC-CIK Infusion Combined with TACE in Treatment of Aggressive-phase Hepatocellular Carcinoma
摘要
Abstract
Objective To explore therapeutic value of different approaches of DC-CIK ( dendritic cell-cytokine-induced killer cells) infusion combined with TACE in treatment of aggressive-phase hepatocellular carcinoma. Methods A total of 146 inpatients with aggressive-phase hepatocellular carcinoma admitted during Mar 1, 2011 and Jan 1, 2014 were divided into group A (n=51)undergoing single TACE therapy, group B (n=46) undergoing TACE and peripheral vein return infusion of DC-CIK and group C (n=49) undergoing TACE and hepatic artery return infusion of DC-CIK. The conditions of AFP (alpha-fetoprotein), liver function, tumor progression, T-cell subset changes, toxic and side-effect and survival rate of patients after the therapy were observed. Results The levels of CD3 and CD4 in group B and levels of CD3, CD4, CD8 and CD4/CD8 after the therapy in group C were significantly higher than those in group A and those before the therapy in the same group (P<0. 05);but the differences between group B and C were not statistically significant (P>0. 05). The differences in progression and survival rates of six months between group A and B were not sta-tistically significant ( P>0. 05 ); while the differences between group C and group A and B were statistically significant (P<0. 05). Conclusion Local use of CIK-DC combined with TACE is safer than the total use of CIK-DC combined with TACE, and it can improve treatment effectiveness and increase life span of patients, which has certain clinical significance.关键词
肝肿瘤/树突细胞/细胞因子诱导杀伤细胞/输注,动脉内/输注,静脉内Key words
Liver neoplasms/Dendritic cells/Cytokine-induced killer cells/Infusions, intra-arterial/Infu-sions, intravenous分类
医药卫生引用本文复制引用
邱宝安,吴印涛,赵文超,夏念信,杨英祥,刘鹏,祝建勇,安阳,王敬晗..不同途径输注DC-CIK联合TACE治疗进展期肝癌的临床研究[J].解放军医药杂志,2015,(3):58-62,5.基金项目
北京市科委“首都市民健康培育项目”(Z141100002114015) （Z141100002114015）
