解放军医药杂志Issue(5)：26-28,3.DOI:10.3969/j.issn.2095-140X.2015.05.008
磷酸肌酸对大鼠子宫缺血再灌注损伤的影响
Effect of Phosphocreatine on Uterine Ischemia-reperfusion Injury in Rats
摘要
Abstract
Objective To study the protective effect and its mechanisms of exogenous creatine phosphate (PCr) preconditioning on uterine ischemia-reperfusion injury in rats. Methods A total of 45 SD female rats were randomly di-vided into sham operation group (n = 15), ischemia-reperfusion group (n = 15) and intervention group (n = 15). The intervention group was given 10 mg/ kg PCr injection via intraperitoneal injection 30 min before ischemia. The activity of superoxide dismutase (SOD) and malondialdehyde (MDA) level in uterine tissues were detected, and the pathological changes of uterus were also observed. Results Compared with those in the sham operation group, the SOD activities were significantly reduced, while MDA levels were significantly increased in ischemia-reperfusion and intervention groups (P < 0. 05); compared with those in ischemia-reperfusion group, the SOD activity was significantly increased, and MDA level was significantly reduced in the intervention group (P < 0. 05). Histopathological observation showed that inflamma-tory reaction in the intervention group was significantly alleviated compared with that in the ischemia-reperfusion group. Conclusion PCr may protect uterine ischemia-reperfusion injury to a certain degree in rats, and the mechanisms may be related with its activation to SOD activity.关键词
磷酸肌酸/再灌注损伤/子宫/大鼠, Sprague-DawleyKey words
Phosphocreatine/Reperfusion injury/Uterus/Rats, Sprague-Dawley分类
医药卫生引用本文复制引用
吕丽贤,张陈彦,安雪丽,张铭娜,张立新..磷酸肌酸对大鼠子宫缺血再灌注损伤的影响[J].解放军医药杂志,2015,(5):26-28,3.基金项目
石家庄市科技指导计划(141462453) （141462453）
