解放军医药杂志Issue(5)：53-55,3.DOI:10.3969/j.issn.2095-140X.2015.05.015
联合检测血清 CEA、AFP、CA19-9对结直肠癌的诊断价值
Value of Combined Detection of Serum CEA, AFP and CA19-9 in Diagnosis of Colorectal Cancer
李延东 1姜训忠 1耿正伟 1杜平 1聂鸿 1赖广华1
作者信息
- 1. 518104 广东 深圳，广州医科大学附属深圳沙井医院病理科
- 折叠
摘要
Abstract
Objective To study the value of combined detection of carcinoembryonic antigen (CEA), alpha fe-toprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) in diagnosis of colorectal cancer. Methods A total of 60 colorectal cancer inpatients during January 2011 and December 2013 were recruited in this study, and levels of serum CEA, AFP and CA19-9 expressions of different tumor parts, differentiated degrees and Dukes clinical stages were ob-served, and then the sensibility and specificity of combined detection for colorectal cancer were analyzed. Results The positive rates of CEA, AFP and CA19-9 in Dukes C + D stage were statistically higher than those in Dukes A + B stage (P < 0. 01). The combined detection sensitivity of CEA, AFP and CA19-9 in diagnosis of colorectal cancer was stronger than those by CEA, AFP and CA19-9 single detection, and the combined detection sensitivity in Dukes C + D stage was stronger than that in Dukes A + B stage (P < 0. 01), but there were no statistically significant in specificity values (P >0. 05). Conclusion The combined detection of CA19-9, AFP and CEA can increase the positive rate in diagnosis of colorectal cancer. The diagnosed value of the combined detection in patients with Dukes (C + D) is high and helpful in judging the pathological stage, assessing prognosis and guiding operational range.关键词
结直肠癌/癌胚抗原/甲胎蛋白/糖抗原 19-9Key words
Colorectal neoplasms/Carcinoembryonic antigen/Alpha-fetoprotein/Carbohydrate antigen 19-9分类
医药卫生引用本文复制引用
李延东,姜训忠,耿正伟,杜平,聂鸿,赖广华..联合检测血清 CEA、AFP、CA19-9对结直肠癌的诊断价值[J].解放军医药杂志,2015,(5):53-55,3.
