解放军医药杂志Issue(5)：69-72,93,5.DOI:10.3969/j.issn.2095-140X.2015.05.019
系统性红斑狼疮380例外周血淋巴细胞亚群变化及临床意义
Changes and Clinical Significance of Peripheral Blood Lymphocyte Subsets in 380 Patients with Systemic Lupus Erythematosus
摘要
Abstract
Objective To investigate the effects of T lymphocyte cell subsets, B-lymphocytes and NK cells changes in the pathogenesy and development of systemic lupus erythematosus (SLE). Methods A total of 380 inpa-tients with SLE and 58 healthy controls taking medical examination were recruited in this study, and then the SLE inpa-tients were divided into inactive SLE subgroup (subgroup A, n = 157), gentle active SLE subgroup (subgroup B, n =79), midrange active SLE subgroup (subgroup C, n = 82) and severe active SLE subgroup (subgroup D, n = 62). The counts and percentages of T-lymphocytes, B-lymphocytes, Th, Ts and NK cells in peripheral blood were detected in the four groups. The correlations between peripheral-blood lymphocyte subsets and disease activity indexes of SLE (SLEDAI) in SLE patients were also analyzed. Results In active subgroups, the values of counts and percentages of T, Th and NK cells and Ts cell count were significantly lower than those in control group, while B-lymphocytes percentage was signifi-cantly higher than those in control group and inactive SLE subgroup (P < 0. 05). The counts of T, Th, Ts, NK cells and percentage of T cell were negatively correlated with SLEDAI score, while percentage of B cell was positively correlated with SLEDAI score ( r = - 0. 347, - 0. 311, - 0. 326, - 0. 351, - 0. 318, 0. 455, P < 0. 05). Conclusion The changes of lymphocyte subsets in peripheral blood of SLE patients may be helpful in evaluating pathogenetic condition and diagnosis of the SLE.关键词
免疫系统疾病/红斑狼疮,系统性/淋巴细胞亚群Key words
Immune system diseases/Lupus erythematosus, systemic/Lymphocyte subsets分类
医药卫生引用本文复制引用
杨宇峰,朱剑,茹晋丽,车国柱,靳志勇,孙慧萍,靳雪琴,陈伟华,李小峰..系统性红斑狼疮380例外周血淋巴细胞亚群变化及临床意义[J].解放军医药杂志,2015,(5):69-72,93,5.基金项目
863计划子课题(012AA02A513) （012AA02A513）
山西省科技攻关项目(20120313025-7) （20120313025-7）
