解放军医药杂志Issue(7)：6-9,4.DOI:10.3969/j.issn.2095-140X.2015.07.002
肾移植术后淋巴细胞亚群的变化与移植肾功能恢复状况分析
Analysis of the Changes of Lymphocyte Subsets and Functional Rehabilitation of Transplanted Kidney after Re-nal Transplantation
摘要
Abstract
Objective To analyze the relationship between the changes of lymphocyte subsets and functional re-habilitation of transplanted kidney after renal transplantation. Methods A total of 40 recipients of renal transplantation without pathogen infection or graft rejection within postoperative 2 weeks, during September 2013 and March 2014 were recruited in the study. According to the value of serum creatinine 7 d after the operation, the recipients were divided into the delayed recovery group (n = 12, the value > 400 μmol/ L) and the stable function group (n = 28). The venous blood samples were respectively collected before and on 3rd , 7th and 14th d after the transplantation, and then the percentage and absolute counting of T and B lymphocyte subsets in peripheral blood were examined. Results The different changes of the percentages of T and B lymphocytes and natural killer (NK) cells were found, while the CD4 + / CD8 + ratios did not significantly change on different time points in the stable function group or delayed recovery group. Compared with those in the stable function group, in the delayed recovery group, CD3 + cell percentage on postoperative 3rd d was significantly decreased, and the percentage of NK cells was significantly increased (P < 0. 05); the values of percentage and absolute count of CD3 + T and CD4 + cells were significantly decreased on postoperative 7th d (P < 0. 05); the percentage of CD4 + cells and ratio of CD4 + / CD8 + were significantly decreased on postoperative 14th d (P < 0. 05). Conclusion Monitoring percentage and absolute count of T and B lymphocyte subsets is beneficial to the rational use of immunosup-pressive agents.关键词
肾移植/B淋巴细胞亚群/T淋巴细胞亚群/监测/免疫学Key words
Kidney transplantation/B-lymphocyte subsets/T-lymphocyte subsets/Monitoring/Immunologic分类
医药卫生引用本文复制引用
高钰,许晓光,王新颖,石炳毅,肖漓,何秀云,黄海燕,樊文梅,魏玉香,马锡慧,孔祥瑞,韩永..肾移植术后淋巴细胞亚群的变化与移植肾功能恢复状况分析[J].解放军医药杂志,2015,(7):6-9,4.基金项目
国家高技术研究发展计划(2012AA021002) （2012AA021002）
首都卫生发展科研专项项目(2014-2-5071) （2014-2-5071）
