湖北民族学院学报（医学版）Issue(4)：24-27,30,5.
滤泡树突细胞肉瘤5例并文献复习
Follicular Dendritic Cell Sarcoma:A Report of 5 Cases and Literature Review
陈鹭姗 1杨映红1
作者信息
- 1. 福建医科大学附属协和医院病理科 福建福州350001
- 折叠
摘要
Abstract
Objective To study the clinicopathologic features, immunophenotype, diagnosis and differential diagnosis of follicular dendritic cell sarcoma.Methods Five cases of follicular dendritic cell sarcoma were evaluated by histological and immunohistochemical staining, and the related literatures were reviewed.Results The masses were detected in left supraclavicular lymph node, nasal cavity, tonsil, the small intestine, and mesojejunum respectively.The age ofpa-tients ranged from 31 to 60 years ( median=45 years ) .Three cas es presents as an enlarging solid mass and local disorders.The other two cases presented with abdominal discomfort or pai n.Grossly, all of the five cases showed grey-white color andmedian texture.Histologically, the neoplastic cells were s pindle-shaped or ovoid and arranged mostly in solid sheets,fasci-cles, whorls or storiform pattern with intermixed sm all lymphocytes.The neoplastic cells of case 2 were epithelioid with significant cytological atypia, and the mitotic we re readily demon-strated.Immunohistochemical study showed that all cases were positive for CD21.There was focal expression of CD23(3/5, 60%) and CD35(4/5,80%).The epithelioid cells were positive for CK and EBER.Of the four cases with follow-up information available ( duration from 9 months to 44 months) , two cases were live well after surgical resection with adjuvant chemo-therapy.One case was alive without any therapy after diagnosis.One case died of metasis at 28 months.Conclusion FDCS is a rare neoplasm, which can be observed in lymph nodes or ex-tranodes.It is seemingly difficult to diagnose and easily confused with other similar lesions.Im-munohistochemical studies are necessary for its diagnosis and differential diagnosis.关键词
滤泡树突细胞肉瘤/免疫组化/病理学Key words
ollicular dendritic cell sarcoma/immunohistochemistry/pathology分类
医药卫生引用本文复制引用
陈鹭姗,杨映红..滤泡树突细胞肉瘤5例并文献复习[J].湖北民族学院学报（医学版）,2014,(4):24-27,30,5.
