湖北民族学院学报（医学版）Issue(2)：4-7,4.
恩施州内外环境硒水平与慢性乙肝患者外周血淋巴细胞亚群改变的研究
The Effects of Selenium Concentration in Body and Environment on the Change of Peripheral Blood LymphocyteS ub sest of Pa tients with Chronic Hepatitis B in Enshi
摘要
Abstract
Objective To explore the correlation between the change of peripheral blood lympho-cyte subsets of patients with chronic hepatitis B and the selenium ( Se) concentration in body and environment in Enshi Tujia and Miao Autonomous Prefecture,Hubei,China.Methods Patient group composed of the patients with hepatitis B virus and control group consisting of people were set up in high-Se area,Se-rich area and low-Se area in Enshi,respectively.Blood sam-ples were collected from different groups in different areas to detect the Se concentration and the amount of peripheral blood lymphocytes of blood.The soil and crops ( mainly rice and tea) were collected to measure the Se concentration in environment in the three types of areas.Hy-dride generation atomic fluorescence spectrometry was utilized to measure the content of Se element, while the peripheral blood lymphocyte subsets were detected by using flow cytome-try.Results Se concentrations in soil (7.73±0.66mg/kg),rice (2.96±0.26mg/kg) and tea (1.58± 0.29 mg/kg) in high-Se area are higher than those in Se-rich area ( 4.76 ±0.92,2.36 ±0.37 and 1.54±0.34 mg/kg) and low-Se area (0.71±0.20, 0.10±0.08 and 0.11±0.05 mg/kg),respectively. There is no obvious difference of Se concentration between the high-Se and Se-rich area,but the other comparisons are of statistical significance ( P<0.01) .The blood Se content in control group is higher than that in patient group in each ( P<0.05) .The blood Se contents in control group and patient group in low-Se area are lower than those in high-Se and Se-rich area,re-spectively ( P<0.05) .In high-Se and low-Se area, the counts of peripheral blood lymphocytes in the patients with chronic hepatitis are evidently lower than those in control group ( P<0.01) , but in Se-rich area the change of the peripheral blood lymphocyte subsets is not as obvious as in high-Se and Se-rich area.Concluis on The blood Se contenst of the patients with chronic hep-atitis in high-Se,Se-rich and low-Se area decrease obviously in comparison with the healthy people.The change of the peripheral blood lymphocyte subsets in the patients with chronic hep-atitis is found to be related to the Se concentration in body and environment.关键词
慢性乙型肝炎/硒/外周血淋巴细胞亚群Key words
chronic hepatitis B/selenium/peripheral blood lymphocyte subsets分类
医药卫生引用本文复制引用
朱旻玥,向艳丽,周晓玲,龙波霖,王凤杰,陈显兵..恩施州内外环境硒水平与慢性乙肝患者外周血淋巴细胞亚群改变的研究[J].湖北民族学院学报（医学版）,2015,(2):4-7,4.基金项目
湖北省卫生厅科研项目（ JX3B 74）；恩施自治州科技局项目（201012）。 （）
