河北医学Issue(8)：1246-1249,4.DOI:10.3969/j.issn.1006-6233.2014.08.005
坦索罗辛联合非那雄胺对老年前列腺增生症患者下尿路症状和 IPSS评分的影响
Efficacy of Combination of Tamsulosin and Finasteride on Urinary Symptoms and IPSS Score for Elderly Patients with BPH
摘要
Abstract
Objective:To observe the efficacy of combination of tamsulosin and finasteride on urinary symptoms and IPSS score for elderly patients with benign prostatic hyperplasia (BPH).Method:96 elderly patients with BPH were selected and randomly divided into observation group and control group , with 48 ca-ses in each group .Subjects in observation group were treated with tamsulosin combined with finasteride ,while subjects in control group were treated with finasteride only .After 3 months of treatment , the clinical ef-ficacy, International Prostate Symptom Score (IPSS), changes of maximum flow rate, residual urine volume and prostate volume of the two groups were compared .The adverse reaction of the two groups was recorded . Result:The effective rate of the observation group was 83.33%, which was significantly higher than that in the control group (P<0.05).After the treatment, the IPSS score of the observation group was (9.47 ±5.08) and the residual urine volume was (32.38 ±12.42) mL.While in the control group, the IPSS score was (13.16 ±3.52), and residual urine volume was (33.59 ±10.47) mL.The IPSS score and residual urine volume of the two groups were significantly lower than those before therapy ( all P<0.05) .The maximum flow rate of the observation group and the control group was (13.86 ±4.68) mL/s and (11.02 ±3.86) mL/s, which were significantly higher than those before the treatment ( P<0.05).After the treatment, the IPSS score of the observation group was significantly lower than the control group , while the maximum urinary flow rate was significantly higher than the control group ( P<0.05) .No obvious adverse reaction of the two groups were happened .Conclusion:Combination of tamsulosin and finasteride has good clinical efficacy in elderly patients with benign prostate hyperplasia .It can improve clinical symptoms , and it is safe .It is worthy of fur-ther application .关键词
前列腺增生症/老年/非那雄胺/坦索罗辛Key words
Benign prostatic hyperplasia/Elderly patients/Finasteride/Tamsulosin引用本文复制引用
程红刚..坦索罗辛联合非那雄胺对老年前列腺增生症患者下尿路症状和 IPSS评分的影响[J].河北医学,2014,(8):1246-1249,4.基金项目
重庆市科研课题， （）
