河北医学Issue(8)：1284-1287,4.DOI:10.3969/j.issn.1006-6233.2014.08.018
乳腺癌组织中 Her2 TopoⅡ表达水平与新辅助化疗近远期疗效的关系研究
Relativity between Her2 Topo II Expression Level in Breast Cancer Tissue and Short/long-term Effect of Neoadjuvant Chemotherapy
吕俊宏 1彭盘俐 1林少欢 1蔡长青 1李玉婵1
作者信息
- 1. 广东省第二人民医院，广东 广州 510317
- 折叠
摘要
Abstract
Objective:To study relativity between human epidermal growth factor receptor 2 ( Her2 ) , topoisomerase II(Topo II)expression level in breast cancer tissue and short /long-term effect of neoadjuvant chemotherapy .Method:96 cases TEC neoadjuvant chemotherapy breast cancer patients were selected , using biopsy before chemotherapy and surgery after chemotherapy to collect lesions and immunohistochemical meth -od to detect level of tissue Her 2, Topo II expression .Result:After neoadjuvant chemotherapy , Her2, Topo II positive expression rate (60.42%, 80.21%) significantly decreased than before (88.54%, 88.54%) (P <0.05); And Her2, Topo II positive expression rate of effective group were significantly lower than ineffective group, Her2, Topo II negative expression rate were also significantly higher than ineffective group ( P <0. 05), and effective rate and 1, 3, 5 year survival rates in Her2, Topo II negative groups were significantly higher than those in positive group (P <0.05).Conclusion:Neoadjuvant chemotherapy can reduce breast tissue Her2, Topo II positive expression to enhance chemotherapy effect , and Her2, Topo II expression level has important clinical value in predicting of short/long-term effect.关键词
乳腺癌/Her2/TopoⅡ/新辅助化疗/疗效Key words
Breast cancer/Her2/TopoII/Neoadjuvant chemotherapy/Curative effect引用本文复制引用
吕俊宏,彭盘俐,林少欢,蔡长青,李玉婵..乳腺癌组织中 Her2 TopoⅡ表达水平与新辅助化疗近远期疗效的关系研究[J].河北医学,2014,(8):1284-1287,4.
