摘要
Abstract
Objective:To explore the influence of enalapril on FIB and D-dimer levels of patients with non-ST-segment elevation myocardial infarction (NSTEMI).Method: 89 patients,whose blood pressure was normal , were divided randomly into the normal treatment group ( 44 cases ) and enalapril group ( 45 ca-ses).The normal group received anticoagulation drug therapy , and enalapril 5mg enalapril orally twice a day respectively .The plasma fibrinogen FIB and D-dimer levels of patients in two groups were detected before treatment and at first , second , forth and sixth weeks after treatment .Result:At first , second week after treatment,The plasma fibrinogen FIB and D-dimer levels of patients in enalapril group was (8.47±0.87)/L, (0.95±0.11)mg/L;(7.98±0.89)g/L,(0.92±0.11)mg/L.While those levels in normal treatment group was (8.45±0.89) g/L,(0.93±0.11)mg/L;(8.26±0.89)g/L,(0.89±0.11) mg/L respectively.There's insignifi-cant difference between them ( P>0.05) .At forth week after treatment ,The plasma fibrinogen FIB and D-di-mer levels of patients in enalapril group and normal treatment group was (6.55±0.98 g/L,0.76±0.08 mg/L) and (7.20±0.79 g/L,0.85±0.11 mg/L),respectively.There's significant difference between them(P<0.01). Conclusion:It can decrease the levels of FIB and D-dimer in patients with NSTEMI , The mechanism may relate with blood coagulation and fibrinolysis after improving the situation of myocardial infarction .关键词
非ST段抬高型心肌梗死/ACEI类药物/依那普利/纤维蛋白原/D-二聚体Key words
Non-ST-segment elevation myocardial infarction/ACEI drug/Enalapril/Blood coagulation and fibrinolysis/D-dimer
