河北医学Issue(9)：1463-1466,4.DOI:10.3969/j.issn.1006-6233.2014.09.019
LEEP 治疗 CIN 合并高危型 HPV感染的近期临床疗效观察
The Short-term Clinical Effects of LEEP on CIN Combined with High-risk HPV Infection
摘要
Abstract
Objective:To investigate the safety and clinical effects of cervical loop electrosurgical exci-sion procedure ( LEEP ) in treatment of cervical intraepithelial neoplasia ( CIN) combined with high-risk hu-man papilloma virus ( HPV) infection.Method:80 eligible patients treated in our hospital were selected and randomly divided into observation group and control group , 40 patients in each group;the observation group used LEEP , while the control group used cervical cold knife conization ( CKC) , and the effects and compli-cations of the surgeries were observed and compared between the patients of the two groups .Result:The op-erative time, intra-operative blood loss and wound healing time of the patients of the observation group were all better than those of the control group , and the differences were statistically significant ( P<0.05) .The in-cidence of a greater bleeding volume during postoperative decrustation than menstrual blood volume of the pa -tients in the observation group was 5.00%, which was lower than that of the control group ( 20.00%) , and the difference was statistically significant ( P<0.05) .All the patients were followed-up for 6 months.Among the patients of the observation group , CIN was clinically cured in 38 patients and remained in 2 patients , while among the patients of the control group , CIN was clinically cured in 37 patients and remained in 3 pa-tients, and the differences were statistically insignificant ( P>0.05).Among the patients of the observation group, high-risk HPV became negative in 28 patients, was improved in 8 patients and unresponsive in 4 pa-tients;while among the patients of the control group , high-risk HPV became negative in 27 patients, was improved in 7 patients and unresponsive in 6 patients , and the differences were statistically insignificant ( P>0.05) .The complication incidence of the patients of the observation group was 2.5%, lower than that of the control group (15.00%), and the difference was statistically significant (P<0.05).Conclusion:It's effec-tive, with less injury, less complication to treat CIN combined with HPV infection by LEEP .关键词
宫颈上皮内瘤变/人乳头瘤病毒/宫颈环形电切术/宫颈冷刀锥切术Key words
Cervical intraepithelial neoplasia/Human papilloma virus/LEEP/Cervical cold knife conization引用本文复制引用
张华,李博..LEEP 治疗 CIN 合并高危型 HPV感染的近期临床疗效观察[J].河北医学,2014,(9):1463-1466,4.基金项目
四川省科技厅资助项目， （）
