河北医学Issue(11)：1818-1821,4.DOI:10.3969/j.issn.1006-6233.2014.11.018
小剂量右美托咪定对全身麻醉高血压患者血流动力学及麻醉效果的影响
Effects of a Small Dose of Dexmedetomidine on the Anesthesia Effects and Hemodynamics in Patients with Hypertension Under General Anesthesia
摘要
Abstract
To investigate the effect of a small dose of dexmedetomidine on the hemodynam-ics and the sedation and anesthesia effects in patients with hypertension under general anesthesia .Method:80 eligible patients were selected and randomly divided into observation group and control group , 40 patients in each group;the patients of the two groups used the same anesthesia method , the patients of the observa-tion group were continuously intravenously micro-pumped with 0.3 μg · kg-1 · h-1 of dexmedetomidine , while the patients of the control group were given with equivalent 0.9%sodium chloride injection .The hemo-dynamic changes , Ramsay sedation scores ( RSS ) and adverse reactions in the patients of the two groups when entering the room ( T0 ) , 1min before intubation ( T1 ) , 0min after intubation ( T2 ) , 2min after intuba-tion ( T3 ) , 1min before extubation ( T4 ) and 2min after extubation were observed .Result: The operative times, intra-operative blood losses , intra-operative colloid infusion volumes , intra-operative crystalline in-fusion volumes , intra-operative urine volumes , anesthesia times , extubation times , palinesthesia times and adverse reaction incidences in the patients of the two groups were similar , and the differences were statistical-ly insignificant (P>0.05).In the patients of the observation group , the systolic blood pressures (SBP), di-astolic blood pressures ( DBP ) and heart rates ( HR) at T1 , T2 , T3 , T4 and T5 were decreased when com-pared with those at T 0 , and the differences were statistically significant ( P<0.05); while in the patients of the control group , the SBP , DBP and HR at T 1 were decreased when compared with those at T 0 , but the SBP, DBP and HR at T2, T3, T4 and T5 were increased when compared with those at T 0, and the differences were statistically significant ( P<0.05);the SBP , DBP and HR at T 0 and T1 in the patients of the two groups were similar, and the differences were statistically insignificant (P>0.05), but the SBP, DBP and HR at T2 , T3 , T4 and T5 in the patients of the control group were higher than those of the observation group , and the differences were statistically significant (P<0.05).The RSS scores at T1, T2, T3, T4 and T5 in the pa-tients of the observation group were higher than those of the control group , and the differences were statisti-cally significant ( P<0.05) .Conclusion: A small dose of dexmedetomidine can inhibit the alarm reactions caused by intubation and extubation and exert sedation effects in patients with hypertension under general an -esthesia , is helpful to the hemodynamic stabilization , and can elevate the safety of anesthesia and surgery .To investigate the effect of a small dose of dexmedetomidine on the hemodynam-ics and the sedation and anesthesia effects in patients with hypertension under general anesthesia .Method:80 eligible patients were selected and randomly divided into observation group and control group , 40 patients in each group;the patients of the two groups used the same anesthesia method , the patients of the observa-tion group were continuously intravenously micro-pumped with 0.3 μg · kg-1 · h-1 of dexmedetomidine , while the patients of the control group were given with equivalent 0.9%sodium chloride injection .The hemo-dynamic changes , Ramsay sedation scores ( RSS ) and adverse reactions in the patients of the two groups when entering the room ( T0 ) , 1min before intubation ( T1 ) , 0min after intubation ( T2 ) , 2min after intuba-tion ( T3 ) , 1min before extubation ( T4 ) and 2min after extubation were observed .Result: The operative times, intra-operative blood losses , intra-operative colloid infusion volumes , intra-operative crystalline in-fusion volumes , intra-operative urine volumes , anesthesia times , extubation times , palinesthesia times and adverse reaction incidences in the patients of the two groups were similar , and the differences were statistical-ly insignificant (P>0.05).In the patients of the observation group , the systolic blood pressures (SBP), di-astolic blood pressures ( DBP ) and heart rates ( HR) at T1 , T2 , T3 , T4 and T5 were decreased when com-pared with those at T 0 , and the differences were statistically significant ( P<0.05); while in the patients of the control group , the SBP , DBP and HR at T 1 were decreased when compared with those at T 0 , but the SBP, DBP and HR at T2, T3, T4 and T5 were increased when compared with those at T 0, and the differences were statistically significant ( P<0.05);the SBP , DBP and HR at T 0 and T1 in the patients of the two groups were similar, and the differences were statistically insignificant (P>0.05), but the SBP, DBP and HR at T2 , T3 , T4 and T5 in the patients of the control group were higher than those of the observation group , and the differences were statistically significant (P<0.05).The RSS scores at T1, T2, T3, T4 and T5 in the pa-tients of the observation group were higher than those of the control group , and the differences were statisti-cally significant ( P<0.05) .Conclusion: A small dose of dexmedetomidine can inhibit the alarm reactions caused by intubation and extubation and exert sedation effects in patients with hypertension under general an -esthesia , is helpful to the hemodynamic stabilization , and can elevate the safety of anesthesia and surgery .关键词
右美托咪定/高血压/血流动力学/全身麻醉Key words
Dexmedetomidine/Hypertension/Hemodynamics/General anesthesia引用本文复制引用
袁川,李红兵..小剂量右美托咪定对全身麻醉高血压患者血流动力学及麻醉效果的影响[J].河北医学,2014,(11):1818-1821,4.基金项目
成都医学院院级科研基金资助项目， （）
