河北医学Issue(1)：118-122,5.DOI:10.3969/j.issn.1006-6233.2015.01.039
血清水通道蛋白－1在喉癌中的表达及临床病理特征的关系
Expression of Serum Aquaporins-1 and the Relationship with Clinicopathological Characteristics in Patients with Laryngeal Carcinoma
摘要
Abstract
Objective:To explore the expression of serum aquaporins-1( AQP-1) and the relationship with clinicopathological characteristics in patients with laryngeal carcinoma .Method: The levels of serum aquaporins-1 detected by enzyme-linked immunosorbent assay (ELISA)in 89 patients with laryngeal carci-noma ( laryngeal carcinoma group ) and 30 healthy subjects ( control group ) ,and the TNM staging ( stage 0, stageⅠ, stageⅡ, stageⅢand stageⅣ) , the degree of tumor differentiation ( poor differentiated , moderately differentiated and well differentiated ) , infiltrating depth ( T1, T2, T3, T4) and lymph node metastasis ( N0, N1, and N2) were analyzed.Result:The levels of serum AQP-1 in laryngeal carcinoma group were signifi-cantly elevated,compared with healthy control group (P <0.05), the levels of serum AQP-1 in any two in TNM Staging tumor differentiation , infiltrating depth and lymph node metastasis were very signifficant differ-ence ( P<0.05) ,except T1 and T2( P>0.05) , the levels of serum AQP-1in patients with laryngeal carcino-ma was a positive correlation with TNM staging infiltrating depth or lymph node metastasis ( P <0.05) .The levels of serum AQP-1in patients with laryngeal carcinoma was negative correlation with tumor differentiation (P <0.05).Conclusion: The levels of serum AQP-1 in patients with laryngeal is increased.There's rela-tionship between serum AQP-1 and TNM staging , infiltrating depth , tumor differentiation or lymph node me-tastasis, The serum AQP-1 levels is expected to become the new serum tumor markers in early diagnosis of laryngeal cancer .关键词
喉癌/水通道蛋白-1/临床病理特征Key words
Laryngeal carcinoma/Aquaporins-1/Clinicopathological characteristics引用本文复制引用
刘权忠,黄国鹏..血清水通道蛋白－1在喉癌中的表达及临床病理特征的关系[J].河北医学,2015,(1):118-122,5.基金项目
重庆市卫生局医学科研计划资助项目， （）
