河北医学Issue(1)：122-125,4.DOI:10.3969/j.issn.1006-6233.2015.01.040
依达拉奉对急性脑梗死患者血清炎性因子及神经功能的影响
Effect of Edaravone on the Nervous Function and Serum Inflammatory Factors in Patients with Acute Cerebral Infarction
摘要
Abstract
Objective:To investigate the effect of edaravone on the serum inflammatory factors in pa-tients with acute cerebral infarction , to promote the rehabilitation of nervous function , and to provide theoret-ic foundations for clinical reasonable medication .Method:80 eligible patients were selected and randomly divided into observation group and control group , 40 patients in each group;the patients of both groups were given with combined modality therapy , those of the observation group were additionally given with edaravone , and the changes in nervous function and serum hypersensitive C reactive protein ( hs-CRP ) , tumor necrosis factor -α( TNF-α) and interleukin-8 ( IL-8) levels between the patients of the two groups were compared . Result:When entering the groups , the serum hs-CRP , TNF-αand IL-8 levels in the patients of the two groups were similar , and the differences were statistically insignificant ( P>0.05);7 days and 14 days after the treatment , the serum hs-CRP , TNF-αand IL-8 levels in the patients of both groups were decreased when compared with those before the therapies , but the decreasing extents of the observation group were greater, and the differences were statistically significant (P<0.05).The rehabilitation of nervous function in the patients of the observation group was significantly better than that of the control group , and the difference was statistically significant (P<0.05).Conclusion: Edaravone can significantly decrease the serum inflam-matory factor levels, lighten the inflammatory reaction and ischemia-reperfusion injury, and promote the re-habilitation of nervous function in patients with acute cerebral infarction , and has positive clinical therapeutic effects.关键词
急性脑梗死/依达拉奉/超敏C反应蛋白/肿瘤坏死因子-α/白细胞介素-8Key words
Acute cerebral infarction/Edaravone/Hypersensitive C reactive protein/Tumor necrosis factor -α/Interleukin-8引用本文复制引用
李忠音,张军..依达拉奉对急性脑梗死患者血清炎性因子及神经功能的影响[J].河北医学,2015,(1):122-125,4.基金项目
泸州医学院附属医院院级基金资助项目， （）
