河北医学Issue(2)：225-228,4.DOI:10.3969/j.issn.1006-6233.2015.02.017
不同剂量布地奈德混悬液雾化吸入辅助治疗毛细支气管炎临床研究∗
Spray Inhalation of Different Doses of Budesonide Suspensions in Adjunctive Treatment of Bronchiolitis
摘要
Abstract
Objective:To compare the safety and clinical efficacy of spray inhalations of different doses of budesonide suspensions in adjunctive treatment of bronchiolitis. Method:90 eligible patients were select-ed and randomly divided into group A, B, and C, with 30 patients in each group. The group A received spray inhalation of budesonide suspension, 1. 0mg 3 times daily; the group B received spray inhalation of budesonide suspension, 0.5mg 3 times daily; and the group C received spray inhalation of budesonide sus-pension, 1.0mg 3 times daily initially, and after symptomatic relief, 0.5mg twice daily;each course of treat-ment was 7 days. And the changes in the clinical symptoms and physical signs in the patients of the three groups were observed and recorded. Result:The differences in times for disappearances of fever, dyspnea, short breath, cough, wheezing sound, and moist rales in the patients between the group A and the group C were all statistically insignificant ( P>0.05) , but the times for disappearances of the symptoms and physical signs in the patients of the group A and the group C were both less than those in the patients of the group B, and the differences were statistically significant ( P<0.05) . After 7-day treatment, the patients of the group A and the group C had similar clinical total response rates, and the difference was statistically insignificant ( P>0.05) , but the patients of both groups had higher clinical total response rates than the patients of the group B, and the differences were statistically significant (P<0.05). One patient of the group A suffered from drowsiness, and another patient of the group suffered from hoarse voice, but no patient in the group B or the group C suffered from any adverse reactions.Conclusion:Use of spray inhalation of a large dose of budes-onide suspension in the acute stage of bronchiolitis can rapidly relieve the clinical symptoms and physical signs in the patients, and a dose reduction after symptomatic relief can reduce the incidence of adverse reac-tions without affecting the clinical efficacy, and consequently can elevate the safety.关键词
毛细支气管炎/布地奈德混悬液/雾化吸入Key words
Bronchiolitis/Budesonide suspension/Spray inhalation引用本文复制引用
何亚薇,冯斌,吴玫,李玉..不同剂量布地奈德混悬液雾化吸入辅助治疗毛细支气管炎临床研究∗[J].河北医学,2015,(2):225-228,4.基金项目
四川省科技厅资助项目,(编号:2013SZ0127) （编号:2013SZ0127）
