河北医学Issue(2)：272-275,4.DOI:10.3969/j.issn.1006-6233.2015.02.032
妊娠糖尿病患者血清脂联素水平变化及其与炎症因子胰岛素抵抗的关系∗
The Relationship of Adiponectin Levels in Serum and Inflammatory Cytokines Insulin Resistance of Gestational Diabetes
摘要
Abstract
Objective:To study the relationship of adiponectin levels in serum and inflammatory cyto-kines, insulin resistance of gestational diabetes. Method: 110 pregnant were selected as pregnancy group from our hospital from June 2012 to June 2014, they were divided into gestational diabetes group ( n = 48 patients) and non-pregnant diabetic group ( n = 62 patients) according to the results of glucose tolerance, healthy women of child bearing age were also selected as the control group(n = 60 patients), the APN, tumor necrosis factor-a ( TNF-a), interleukin ( IL) -6 of inductees were detected in enzyme-linked immu-nosorbent assay ( ELISA), the level of high-sensitivity C-reactive protein ( hs-CRP ) were detected in im-munoturbidimetry, the fasting insulin ( Fins ), homeostasis model assessment of insulin resistance insulin ( HOMA-IR) and triglyceride level of all inductees were detected. Result: The level of IL-6, hs-CRP, TNF-a, TG, Fins and HOMA-IR of the pregnancy group were (29.1 ± 0.4) pg / mL, (4.3 ± 0.2) ng /mL, (31.3 ± 0.5) pg / mL, (1.8 ± 0.1) mmoL / L, (9.4 ± 0.2) mU / L, (2.1 ± 0.3) significantly high-er than the control group, the difference was statistically significant(t=8.792,9.173,9.068,10.026,9.957, 9.819,P=0.038,0.027,0.029,0.021,0.023,0.025), the level of APN was (10.2±0.2)mg/L significantly lower than the control group, the difference was statistically significant ( t=8.968,P=0.032);the IL-6, hs-CRP, TNF-a and HOMA-IR of the gestational diabetes group were (36.1 ± 0.3) pg / mL, (6.9 ± 0.3) ng/ mL, (46.7 ± 0.9) pg / mL and (3.0 ± 0.2) significantly higher than the non-pregnant diabetic group, the difference was statistically significant(t=10.021,9.796,8.935,9.012,P=0.026,0.031,0.034,0.029), the level of APN was (7.1±0.2)mg/L,which was significantly lower than the non-pregnant diabetic group, the difference was statistically significant( t=9.052,P=0.019); APN and IL-6, hs-CRP, TNF-a, TG, Fins, HOMA-IR had a negative correlation( r=-0.389,-0.381,-0.382,-0.402,-0.391,P=0.019,0.023, 0.025,0.018,0.031). Conclusion: The level of APN of gestational diabetes can significantly reduce, can cause inflammation imbalance, may be an important factor in insulin resistance.关键词
妊娠糖尿病/脂联素/炎症因子/胰岛素抵抗Key words
Gestational diabetes/Adiponectin/Inflammatory cytokines/Insulin resistance引用本文复制引用
张淑芳,于易,田晓蕾,陈梅..妊娠糖尿病患者血清脂联素水平变化及其与炎症因子胰岛素抵抗的关系∗[J].河北医学,2015,(2):272-275,4.基金项目
广东省深圳市南山区卫生科技资助项目,(编号:南科研卫2013047号) （编号:南科研卫2013047号）
