河北医学Issue(4)：532-535,536,5.DOI:10.3969/j.issn.1006-6233.2015.04.002
比索洛尔治疗老年高血压伴心功能不全患者的临床疗效观察
Clinical Effect of Bisoprolol in Treating Elderly Patients with Hypertension and Cardai c Insufficiency
摘要
Abstract
Objective:To observe the clinical effect of bisoprolol in treating elderly patients with hyper-tension and cardiac insufficiency .Method:100 patients were enrolled and randomly divided into treatment group (n=50) and control group (n=50).The control group received routine treatment , while bisoprolol was added to treatment group for a course of 8 weeks.The blood pressure, heart rate, left ventricular mass index (LVMI), interventricular septum thickness (IVS), left ventricular posterior wall thickness (LVWP),left ventricular end-diastolic volume ( LVEDV ) , left ventricular end systolic volume ( LVESV ) , ejection fraction ( EF) and diastolic function index ( E/A) before and after the treatment were observed .Blood bio-chemical indicators including brain natriuretic peptide ( BNP ) , vascular endothelial growth factor ( VEGF) , high-sensitivity C-reactive protein ( hc-CRP ) and hepatorenal functions were also recorded .Result: The systolic pressure , diastolic pressure and heart rate of the treatment group were obviously lower than those be-fore the treatment ( P<0.01) , and cardiac function indicators ( except for NYHA grading IV ) were all better than those before the treatment (P<00.5 ), among which LVEDV, LVESV, LVMI, EF and E/A were supe-rior to those of control group (P<0.05).BNP, VEGF and hs-CRP of the treatment group decreased remark-ably after the treatment ( P<00.1 ) , and BNP level of the treatment was superior to that of control group ( P<0.01) .The blood routine and hepatorenal function examination of the two groups before and after the treat-ment all showed normal results, and the difference was no statistical significance (P>0.05).Conclusion:Bisoprolol is effective and safe in treating patients with hypertension and cardiac insufficiency .关键词
比索洛尔/高血压/心功能不全Key words
Bisoprolol/Hypertension/Cardiac insufficiency引用本文复制引用
诺敏,鹿亚平,张海龙,冯立新,刘先霞,徐勇..比索洛尔治疗老年高血压伴心功能不全患者的临床疗效观察[J].河北医学,2015,(4):532-535,536,5.基金项目
国家自然科学基金面上基金项目，（编号81371647）；海南省社会发展基金项目， （）
