河北医学Issue(4)：591-594,4.DOI:10.3969/j.issn.1006-6233.2015.04.021
合用与换用阿立哌唑对已绝经女性精神分裂症患者催乳素水平影响的对照研究
Control Study of Combined with Aripiprazole or Switching to Aripiprazole on Prolactin Levels in Postmenopausal Women with Schizophrenia
倪静 1戴兴海 1朱欣彦 2沈涛 1周颖 1田良辉 1咸晶 1徐颺1
作者信息
- 1. 上海市黄浦区精神卫生中心，上海 黄浦区 200003
- 2. 同济大学附属东方医院消化科，上海 黄浦区 200003
- 折叠
摘要
Abstract
Objective: To investigate the role of aripiprazole in prolactin ( PRL ) metabolism through comparing the PRL levels of the postmenopausal women with schizophrenia and hyperprolactinemia .Method:90 women with schizophrenia and hyperprolactinemia were randomly divided into 2 groups:group A with 45 cases, former drugs plus aripiprazole 5mg once a day for 12 weeks) and group B with 45 cases, Aripiprazole 14.78±4.76mg once a day for 12 weeks).Then examined the PRL levels at 5 time points:prior treatment, 2 weeks, 4 weeks, 8 weeks, 12 weeks and accomplished the PANSS scales at the time points stated above as well.Result:According to the result of repeated measures ANOVA , the PRL levels of the 2 groups had no significant differences ( F=3.507,P=0.064) and had interaction between the groups and time points ( P=0. 002), suggesting that PRL was influenced by different treatment of aripiprazole and time .The score of PAN-SS scales had no significant differences (F=0.145,P=0.705).Conclusion:Aripiprazole may down-regulate the expression of the PRL levels of women with schizophrenia and hyperprolactinemia .关键词
阿立哌唑/绝经女性/精神分裂症/高催乳素血症Key words
Aripiprazole/Postmenopausal women/Schizophrenia/Hyperprolactinemia引用本文复制引用
倪静,戴兴海,朱欣彦,沈涛,周颖,田良辉,咸晶,徐颺..合用与换用阿立哌唑对已绝经女性精神分裂症患者催乳素水平影响的对照研究[J].河北医学,2015,(4):591-594,4.
