河北医学Issue(6)：914-917,4.DOI:10.3969/j.issn.1006-6233.2015.06.011
HIF－1αE－cadherin在乳腺中的表达及意义
Expression of HIF-1αand E-cadherin in Breast Cancer and the Significance
闫哲 1白立立 1赵伟静 2张洪珍3
作者信息
- 1. 河北医科大 学，河北 石家庄 050017
- 2. 河北红十字会博爱医院肿瘤科，河北 石家庄 050000
- 3. 河北省人民医院肿瘤五科，河北 石家庄 050000
- 折叠
摘要
Abstract
Objective:To investigate the significance and correlation of HIF-1αand E-cadherin in car-cinogenesis and development of breast cancer .Method:Immunohistochemical staining was undertaken to an-alyze the expression of HIF-1αand E-cadherin in 30 cases of the adjacent normal breast tissues ,40 cases of mammary gland hyperplasia and 60 cases of breast cancer .Result:The expression of HIF-1αin the normal and mammary gland hyperplasia breast tissues were all nagative , and in breast carcinoma , the positive rate of HIF-1αexpression was 63.3%(38/60),with significant differences among them (P<0.05).The expression of HIF-1αwas closely correlated with pathological grade and clinical stage (P<0.05),but not with age.E-cadherin mainly expressed in membranes , the positive expression rate in normal、mammary gland hyperplasia and cancer tissues was 93.3%(28/30), 80.0%(31/40) and 55.0%(33/60).There was no difference of E-cadherin expression between normal and mammary gland hyperplasia breast tissues (P>0.05),but positive expression rate of E-cadherin in breast cancer was much lower than normal and mammary gland hyperplasia
<br> tissues(P<0.05).The expression of E-cadherin was correlated with pathological grade and clinical stage (P<0.05),but not with age.The expressions of HIF-1αand E-cad herin in breast cancer were negatively corre-lated(r=-0.433, P<0.01).Conclusion:The abnormal expressions of HIF-1αand E-cadherin are early e-vents in breast cancer .Both may exert important effects in carcinogenesis and development of the breast canc-er.Synchronous detection of HIF-1αand E-cadherin is of great value in judging the malignancy of breast disease in order to prompt prognosis .关键词
HIF-1α/E-cadherin/乳腺癌Key words
HIF-1α/E-cadherin/Breast cancer引用本文复制引用
闫哲,白立立,赵伟静,张洪珍..HIF－1αE－cadherin在乳腺中的表达及意义[J].河北医学,2015,(6):914-917,4.
