河北医学Issue(7)：1057-1061,5.DOI:10.3969/j.issn.1006-6233.2015.07.001
DLG1基因多态性与炎症性肠病遗传易感性研究
Study on DLG1 Gene Polymorphism and Genetic Susceptibility to Inflammatory Bowel Disease
摘要
Abstract
Objective:To investigate the association between DLG1 polymorphism and genetic suscepti-bility of inflammatory bowel disease(IBD).Method: DLG1 R278Q(chr3_196865242) was analyzed with PCR-based RFLP and direct sequencing, including 4 cases with CD and 11 undiagnosed samples from the same family, 185 with sporadic CD,160 with sporadic UC, and 463 unrelated healthy controls.Results:The frequency of“A”allele of site chr3_196865242 was 18.9%and 60%in sporadic CD group and CJ group re-spectively,significantly higher than that in the normal control group(11.7%, P=0.015 and P <0.05).There was no statistical significance between cases of sporadic UC patients and normal control group ( P=0.778) . Conclusion:We have confirmed the polymorphisms of the chr3_196865242 loci in 9 exon of DLG1.It sug-gest that the SNP may be associated with a significantly higher risk for developing CD in Chinese Han popu-lation.关键词
DLG1/基因多态性/遗传易感性/炎症性肠病/克罗思病Key words
DLG 1/Gene Polymorphism/Genetic susceptibility/Inflammatory bowel disease/Crohn's disease引用本文复制引用
王静晖,许淑芳,王晓兵,刘适,王格,周瑞,夏冰..DLG1基因多态性与炎症性肠病遗传易感性研究[J].河北医学,2015,(7):1057-1061,5.基金项目
国家自然科学基金， （）
