河北医学Issue(8)：1384-1387,4.DOI:10.3969/j.issn.1006-6233.2015.08.005
静脉预注右美托咪定在罗哌卡因蛛网膜下腔阻滞麻醉中的临床应用研究
Clinical Study on Intravenously Pre-injected Dexmedetomidine in Ropivacaine Subarachnoid Block Anesthesia
摘要
Abstract
Ob jective: To investigate the effect of intravenously pre-injected dexmedetomidine on thevital signs and anaesthetic effects in patients under ropivacaine subarachnoid block anesthesia.Method: Atotal of 89 eligible patients were selected and randomly divided into observation group (45 patients) and controlgroup (44 patients).The observation group used dexmedetomidine before anesthesia, while the controlgroup used an equivalent volume of 0.9%sodium chloride injection, and the anaesthetic effects and Ramsaysedation scores, mean arterial pressures (MAP), and heart rates (HR) when entering operation rooms(T 0), at 10min after pre-injection (T 1), when puncture for anesthesia (T 2), at 30min after pre-injection(T 3), at 60min after pre-injection (T 4), at the end of surgeries (T 5), at 10min after the surgeries (T6 ),and at 30min after the surgeries (T7) were observed and recorded.Result: The patients of the two groupshad similar Ramsay sedation scores at T0 , and the difference was statistically insignificant (P>0.05); at T1 ~T7 , the patients of the observation group had higher Ramsay sedation scores than those of the observationgroup at T0 , and higher than those at the corresponding time points of the control group, and the differenceswere statistically significant (P<0.05).The patients of the two groups had similar maximum sensory blocklevels and times of motor block to Bromage 3, and the differences were statistically insignificant (P>0.05);but the observation group had longer times to achieve sensory block regression to the S 1 and to achieve motorblock recovery to Bromage0 than the control group, and the differences were statistically significant (P<0.05).The patients of the two groups had similar MAP and HR at T 0 , and the differences were statistically insignificant(P>0.05); The patients of the two groups had similar MAP at T 1 ~T7, and the differences werestatistically insignificant (P>0.05); the patients of the observation group had lower HR than the controlgroup at T1 ~T7, and the differences were statistically significant (P<0.05).Conclusion: Intravenously pre-injected dexmedetomidine can prolong the durations of motor and sensatory blocks of ropivacaine subarachnoidblock anesthesia, has insignificant effect on blood pressure, and consequently can maintain the stabilizationof the circulatory system.关键词
右美托咪定/罗哌卡因/蛛网膜下腔阻滞麻醉Key words
Dexmedetomidine/Ropivacaine/Subarachnoid block anesthesia引用本文复制引用
胡艳,林敏..静脉预注右美托咪定在罗哌卡因蛛网膜下腔阻滞麻醉中的临床应用研究[J].河北医学,2015,(8):1384-1387,4.基金项目
四川省卫生科研课题， （）
