河北医学Issue(10)：1588-1590,3.DOI:10.3969/j.issn.1006-6233.2015.10.002
多耐药基因在乳腺癌组织中的表达及价值
The Expression and Clinical Significanc e of Multidrug Resistance Gene in Breast Cancer Tissues
摘要
Abstract
Objective:To observe the expression of multidrug resistance gene ( MDR1) and its encoding glycoprotein ( P-gp) and clinical value in breast cancer .Methods:Selected the complete medical records of breast cancer radical mastectomy of breast tissue specimens of 84 copies, using S-P method of immunohisto-chemical staining to detect P-gp, GST-πand heat shock protein(HSP70), the expression of p53, using the Kendall's Taub correlation analysis between P-gp, p53,GST-π, and HSP70, a PI the relationship between the expression of p53.Result:The positive rate of P-gp expression was 50%(42/84), the positive rate of HSP70 expression was 61.9%(52/84), the positive rate of p53 expression was 52.4%(44/84), GST-class expression positive rate was 40.5%(34/84);correlation analysis showed that GST-πand P-gp, PI no syn-ergistic expression (r=0.146, P>0.05), HSP70 and p53 have synergistic expression (r=0.626, P<0.05), p53 and P-gp have synergistic expression ( r=0.763, P<0.05);the expression of P-gp of breast cancer 10 years survival rate has obvious effect .Multivariate prognostic models of human breast cancer COX analysis showed that the factors of age , GST-π, PI expression do not have independent prognostic significance;clini-cal staging , tissue have independent prognostic significance grading , P-gp expression , p53 expression , HSP70 expression.Conclusion:At the same time, the expression of MDR1, HSP7, p53 and GST-π, for clinical drug resistance of breast cancer judgment to provide more comprehensive information .关键词
乳腺癌/耐/药/MDR1/HSP70/GST-π/p53Key words
Breast cancer/Drug resistance/MDR1/HSP70/GST-π/p53引用本文复制引用
林慧梅,安玉芳,张凡..多耐药基因在乳腺癌组织中的表达及价值[J].河北医学,2015,(10):1588-1590,3.基金项目
国家十一五科技支撑项目， （）
