摘要
Abstract
Objective:To investigate the non-invasive hemodynamic effection during the general anes-thesia given dexmedetomidine and propofol under the same anesthesia depth .Method:64 patients ,ASAⅠ~Ⅱlevel ,under the elective subtotal thyroidectomy , were randomly divided into two groups:dexmedetomi-dine group (group D,n=32) and propofol group ( group C,n=32), Atropine 0.5mg, imidazole 4mg, Dexmedetomidine [ 1.0μg/kg at induction of anesthesia with 10min , then 0.5 μg · kg-1 · h-1 for mainte-nance of anesthesia] fentanyl 0.25mg, rocuronium 50mg were given to intubate, while Propofol [100mg at induction of anesthesia ,then set to target the mass concentration of 4 ~5mg/L for maintenance of anesthe-sia]were given to the group C, and the others were the same.During the intraoperative,both of the groups were used the cis-atracurium and remifentanil to maintain of anesthesia , used the Bioz .com to monitor the noninvasive hemodynamic reaction and used the BIS to maintain the same anesthesia depth 40~50 .Heart rate (HR), mean arterial pressure(MAP), cardiac index(CI), stroke volume index (SI), systemic vascu-lar resistance ( SVR) were recorded before the operation ( T1 ) , before the intubation ( T2 ) , after the intuba-tion (T3), the beginning of operation (T4), 10min of the operation(T5), before the extubation(T6),after the extubation(T7).Result:In the entire surgical procedure, under the same level of the BIS, two groups of patients in the use of remifentanil dose per unit time difference has statistical significance ,dose was signifi-cantly lower in group D.For HR, MAP, SI, SVR,with different anesthetic methods and phase , the change tendency is different,except the HR, group D is more steady (P <0.05).For CI,with different anesthesia phase, change tendency is not different .Conclusion:Dexmedetomidine [1.0μg/kg at induction of anesthe-sia with 10min,then 0.5μg· kg-1 · h-1 for maintenance of anesthesia ] have sedation analgesia effect , inhi-bition of stress reaction , and is more stabile than propofol for hemodynamic effection .关键词
右美托咪定/丙泊酚/血流动力学/麻醉药Key words
Dexmedetomidine/Propofol/Hemodynamic/Anesthetics
