郑州大学学报（医学版）Issue(3)：386-390,5.DOI:10.13705/j.issn.1671-6825.2014.03.027
急性髓系白血病患者骨髓WT1基因的表达与预后的关系
Prognostic value of WT1 expression in bone marrow for acute myeloid leukemia
万鼎铭 1边志磊 1刘延方 1曹伟杰 1张媛 2李涛 1何海燕 3玄中乾1
作者信息
- 1. 郑州大学第一附属医院血液科郑州450052
- 2. 新乡医学院第一附属医院血液科 新乡453100
- 3. 郑州大学血液病研究所郑州450052
- 折叠
摘要
Abstract
Aim:To investigate the relationship between WT 1 gene expression level in bone marrow of acute myeloid leukemia ( AML) patients and the prognosis .Methods:A total of 122 newly diagnosed AML patients were subjected to de-tect WT1 expression level in bone marrow by real time quantitative reverse transcription-PCR method ,and the complete re-mission rate after the first induction chemotherapy (CR1), two-year leukemia-free survival rate(LFS) and two-year overall survival rate ( OS) were calculated .A total of 21 cases of non-AML were the control .Results:The median expression level of WT1 in AML patients was 0.677(0.336,0.763), which was higher than that of control [0.007(0.002,0.080),Z=2.620,P<0.001].With regard to AML-M3 patients,CR1, two-year LFS and OS of the patients with high expression level of WT1 was similar to those of the patients with low expression level of WT 1.With regard to non AML-M3 patients, CR1 in the high WT1 expression group was 52.3%, lower than that of 82.6%in the low WT1 expression group (χ2 =9.476,P=0.002);the two-year leukemia-free survival curve and overall survival curve of high WT 1 expression patients differed from those of low WT1 expression patients(χ2 =4.698,5.410,P<0.05),and two-year LFS and OS of high WT1 expression pa-tients were 33.3%and 36.0%,lower than 53.7%and 57.7%of the low WT1 expression patients.Conclusion:WT1 ex-pression level in bone marrow could be an useful prognosis marker for AML patients .关键词
急性髓系白血病/WT1基因/预后Key words
acute myeloid leukemia/WT1 gene/prognosis分类
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万鼎铭,边志磊,刘延方,曹伟杰,张媛,李涛,何海燕,玄中乾..急性髓系白血病患者骨髓WT1基因的表达与预后的关系[J].郑州大学学报（医学版）,2014,(3):386-390,5.
