郑州大学学报（医学版）Issue(5)：678-680,3.DOI:10.13705/j.issn.1671-6825.2014.05.023
卷柏黄酮对小鼠中枢神经系统的影响
General pharmacology of selaginella Tamariscina (Beauv .) spring fla-vonoids on central nervous system
摘要
Abstract
Aim:To study the effect of selaginella Tamariscina ( Beauv .) spring flavonoids on mouse central nervous system.Methods:The mice freedom movement , coordinate motion and harmonious movement drop asleep persistent times after giving pentobarbitale sodium were observed by methods animal behaviour observation .Results:The mice freedom movement can be reduce with the time in the three doses and especially for the high dose , it has a significant decrease in the mice freedom movement(Fgroup =9.819,Ftime =4.480,Fintercross =2.489, P<0.01).Compared with the normal group, there was no effect on coordinate motion in the middle and low dose , while a significant decrease in the high dose group (Fgroup =93.265,Ftime =287.416, Fintercross =88.062,P<0.01).Selaginella Tamariscina at these three dose has no effect on harmonious movement drop asleep persistent times after giving pentobarbitale sodium compared with the normal group (P>0.05).Conclusion:Selaginella Tamariscina(Beauv.) spring flavonoids of high dose has a sedation in mice .关键词
卷柏黄酮/中枢神经系统/小鼠Key words
flavonoids in selaginella Tamariscina(Beauv.) spring/central nervous system/general pharmacology/mouse分类
医药卫生引用本文复制引用
孙曙光,李玉洁,李玲玲,袁培培,赫金丽,王小兰..卷柏黄酮对小鼠中枢神经系统的影响[J].郑州大学学报（医学版）,2014,(5):678-680,3.基金项目
国家自然科学基金资助项目81073034；国家“重大新药创制”科技重大专项基金资助项目2013ZX09102022 （）
