赵鹏 1朱红灿 2李玉生 3赵幸娟 3郑亚珂 1李薇3
作者信息
- 1. 郑州市第一人民医院神经内科郑州450003
- 2. 郑州大学第一附属医院神经内科郑州450052
- 3. 郑州大学第一附属医院神经内科郑州450052
- 折叠
摘要
Abstract
Aim:To study the incidence , clinical characteristics and related factors of cognitive dysfunction in Parkin-son′s disease(PD).Methods:A total of 52 patients with Parkinson′s disease (PD group) and 58 healthy patients (nor-mal group) were assessed by Montreal cognitive assessment (MoCA) scale,to study the incidence of cognitive dysfunction , clinical characteristics in PD patients and the relationship between the PD patients with cognitive dysfunction and age , du-ration, Hoehn-Yahr grade, UPDRS score.Results:The MoCA score in PD group was lower than that in normal group (t=8.036,P<0.001), the incidence of cognitive dysfunction was 57.7% in the PD group(χ2 =19.200,P<0.001).The main features of cognitive dysfunction in PD patients showed attention and concentration , executive functions , memory, de-layed recall, language skills, visual ability, abstract thinking and ability of orientation , retardation, etc.Logistic regression analysis showed that cognitive dysfunction in PD group was positively related with the severity of disease condition ( H-Y classification), duration, UPDRS (Part Ⅰ) score and UPDRS (Part Ⅱ) score(OR:5.464,6.172,1.138,1.305;95%CI:1.915-10.136,0.068-0.872,1.017-1.358,1.316-11.014).Conclusion: The incidence of cognitive dysfunc-tion in PD patients is high .There are many forms of clinical manifestations , and the extent of these manifestations is corre-lated with disease duration , severity and UPDRS score .关键词
帕金森病/认知功能障碍/蒙特利尔认知评估/影响因素Key words
Parkinson′s disease/cognitive dysfunction/Montreal cognitive assessment/influence factor分类
医药卫生
