郑州大学学报（医学版）Issue(1)：78-82,5.DOI:10.13705/j.issn.1671-6825.2015.01.022
经皮冠状动脉封堵法制备中华小型猪急性心肌梗死模型及血清 H－FABP动态变化的观察
Establishment of AMI Chinese mini-swine model with percutaneous coro-nary occlusion and observation on dynamic change of serum H-FABP level
段娜娜 1陈士芳 1孟雅丽 1闫鹏 1刘向勇 1程建新 1王绍欣 1王丽平 1王宏运 1董平栓 1汪砚雨 1王可 1李转珍 1魏丽娟2
作者信息
- 1. 河南科技大学第一附属医院心血管内科洛阳471003
- 2. 河南科技大学第一附属医院麻醉科洛阳471003
- 折叠
摘要
Abstract
Aim:To evaluate the mean of percutaneous coronary occlusion to establish Chinese mini-swine acute myo-cardial infarction(AMI) model,and observe dynamic change of serum heart-type fatty acid-binding protein(H-FABP). Methods:The obtuse marginal ( OM) branch of 16 Chinese mini-swines were blocked by gelatin sponge via microcatheter under general anesthesia through Seldinger right femoral artery puncture after coronary angiography .Serum H-FABP con-centrations before AMI and at the 0.5,1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0, 24.0 and 48.0 h after AMI were de-termined.Results:The OM branches of 15 Chinese mini-swines were successfully blocked .Serum H-FABP began to in-crease 0.5 h after operation, and reached the peak after 8.0 h,and then gradually fell back to normal after 24.0 h.Con-clusion:It is practical to copy mini-swine AMI model by percutaneous coronary occlusion .Monitoring the serum H-FABP concentrations can provide clinical data for early diagnosis and treatment of patients with AMI .关键词
急性心肌梗死/心脏型脂肪酸结合蛋白/动物模型/中华小型猪Key words
acute myocardial infarction/heart-type fatty acid-binding protein/animal model/Chinese mini-swine分类
医药卫生引用本文复制引用
段娜娜,陈士芳,孟雅丽,闫鹏,刘向勇,程建新,王绍欣,王丽平,王宏运,董平栓,汪砚雨,王可,李转珍,魏丽娟..经皮冠状动脉封堵法制备中华小型猪急性心肌梗死模型及血清 H－FABP动态变化的观察[J].郑州大学学报（医学版）,2015,(1):78-82,5.
