郑州大学学报（医学版）Issue(1)：134-137,138,5.DOI:10.13705/j.issn.1671-6825.2015.01.039
苯甲酸钠多次给药对大鼠肝肾功能的影响
Effects of sodium benzoate on liver and kidney in rats
摘要
Abstract
Aim:To study the effects of sodium benzoate on liver and kidney in rats .Methods: Fifty healthy SD rats were allocated into 5 groups and treated with sodium benzoate (0.1,0.2,0.4 g/kg),potassium sorbate(0.2 g/kg) and normal saline by gavage for 4 weeks.The serum indicators such as ALT , AST, ALP, GGT, TP, ALB, TBIL, BUN,Cre, and UA were determined and the liver and renal histology of the rats was observed .Results:Rats in each dose group of sodium ben-zoate had abnormal serum biochemical indicators , especially in high dose group .Furthermore, rats in sodium benzoate high dose group showed obvious pathological abnormalities in liver .Rats in all groups showed no pathological changes in kidneys . Conclusion:The frequent use of sodium benzoate could do harms to the kidney and liver especially to the liver in rats .关键词
苯甲酸钠/大鼠/肝脏/肾脏Key words
sodium benzoate/rat/liver/kidney分类
医药卫生引用本文复制引用
李锦玉,李荣欣,李京路,毕红征..苯甲酸钠多次给药对大鼠肝肾功能的影响[J].郑州大学学报（医学版）,2015,(1):134-137,138,5.基金项目
大学生创新实验项目201310459015 （）
