郑州大学学报（医学版）Issue(2)：229-232,4.DOI:10.13705/j.issn.1671-6825.2015.02.022
胎膜早破和绒毛膜羊膜炎患者胎膜组织中 MMP-9、MIF 的表达和羊水中 IL-6水平检测
Expressions of MMP-9, MIF in fetal membranes and IL-6 level in amniot-ic fluid of pregnant women with premature rupture of membranes or cho-rioamnionitis
摘要
Abstract
Aim:To explore the changes of the expressions of MMP-9,MIF in fetal membranes and IL-6 level in amni-otic fluid of pregnant women with premature rupture of membranes (PROM) or chorioamnionitis(CAM).Methods:A total of 50 full-term pregnant women with PROM(PROM group) and 60 cases without PROM(control group) underwent term ce-sarean delivery were selected to detect the expressions of MMP-9,MIF in fetal membranes using immunohistochemical meth-od and the level of IL-6 in amniotic fluid using ELISA.Results:The CAM incidence, the level of IL-6 in amniotic fluid, and MMP-9,MIF expressions of PROM group were higher than those of the control group (χ2 =23.973,t=5.817,Z=3.507,2.678,P<0.05).The indexes mentioned above of the women with CAM diagnosed histologically were higher than those of non-CAM women(P<0.05).Conclusion: PROM and CAM might be causal; imbalance among MMP-9, MIF and IL-6 may lead to CAM .关键词
胎膜早破/绒毛膜羊膜炎/基质金属蛋白酶-9/巨噬细胞移动抑制因子/白细胞介素-6Key words
premature rupture of membrane/chorioamnionitis/MMP-9/MIF/IL-6分类
医药卫生引用本文复制引用
郭华峰,杨筱青,古雅丽,陈慧萍..胎膜早破和绒毛膜羊膜炎患者胎膜组织中 MMP-9、MIF 的表达和羊水中 IL-6水平检测[J].郑州大学学报（医学版）,2015,(2):229-232,4.基金项目
河南省科技发展计划项目132102310144 （）
