郑州大学学报（医学版）Issue(2)：252-255,4.DOI:10.13705/j.issn.1671-6825.2015.02.028
盆腔器官脱垂患者阴道壁和子宫骶、主韧带组织中神经纤维特点和 VIP、NPY蛋白的表达
Expressions of VIP and NPY in vaginal wall and uterosacral and cardinal ligaments of pelvic organ prolapse patients
摘要
Abstract
Aim:To research the nerve fiber damage and vasoactive intestinal peptide ( VIP) ,neuropeptide Y ( NPY) expression in vaginal wall , uterosacral and cardinal ligaments of patients with pelvic organ prolapsed ( POP) ,and to investi-gate their relation with occurrence of POP .Methods:A total of 15 patients with POP were allocated into three groups:mild POP group(7 patients),severe POP group(8 patients),and 20 patients without POP as the control .The uterosacral, cardi-nal ligament and anterior vaginal tissues were obtained .HE staining and immunohistochemical staining were applied to ob-serve the histological structure ,the density of nerve fiber bundles and the expressions of VIP and NPY proteins around vas -cular.Results:There was significant difference in parity among the three groups and the parity of patients in POP groups were higher(F=12.196,P<0.001).The structure of vaginal wall , uterosacral and cardinal ligaments in patients with POP were weak .The expressions of perivascular VIP and NPY proteins of vaginal wall ,uterosacral and cardinal ligaments among the three groups were significantly different (F=17.312,19.825,18.312,16.327,20.721,22.625,P<0.05),and which were higher in POP groups than those in control group ,and were higher in severe POP group than those in the mild POP group.Conclusion:Parity maybe a risk factor for the occurrence of POP .VIP and NPY may play important roles in occur-rence and development of POP .关键词
盆腔器官脱垂/血管活性肠肽/神经肽Y/神经损伤Key words
pelvic organ prolapse/vasoactive intestinal peptide/neuropeptide Y/nerve injury分类
医药卫生引用本文复制引用
邵世清,韦业平,邓丽,张丽滢,刘佶,王佳祺,雷静霞..盆腔器官脱垂患者阴道壁和子宫骶、主韧带组织中神经纤维特点和 VIP、NPY蛋白的表达[J].郑州大学学报（医学版）,2015,(2):252-255,4.基金项目
广西壮族自治区科技厅基金支持项目桂科攻10124001 A-46 （）
