中医学报Issue(6)：766-768,3.
水蛭、脉血康对急性血瘀模型大鼠血液流变学及凝血功能的影响
Influence of Hirudo and Maixuekang on Hemorheology and Blood Coagulation Functions on Acute Blood Stasis Model of Rats
摘要
Abstract
Objective:To observe the effect of Hirudo and Maixuekang on hemorheology,blood coagulation system in acute blood stasis model of rats. Methods:After two weeks of continuous administration,the models of rats were prepared by injection of Adr together with being put into ice-water for several minuters. The whole blood viscosity,plasma viscosity,haematocrit,red cell deformation index and red cell assembling index were tested to observe the effects of Hirudo on the hemorheology of blood stasis rats. The prothrombin time(PT), activated partial thromboplastin time(APTT),thrombin time(TT),plasma fibrinogen(FIB),platelet aggregation rate and the activity of coagulation factor FⅡ,FⅤ,FⅦ,FⅧ,FⅩ were tested to observe the effects of Hirudo on the blood coagulation function of blood stasis rats. Results:Hirudo can significantly reduce blood viscosity,plasma viscosity and platelet aggregation rate,inhibit the activity of F Ⅱ, prolong APTT and TT of blood stasis model rats. Maixuekang can decrease whole blood viscosity and platelet aggregation rate,prolong APTT and TT. Conclusion:Hirudo and Maixuekang can improve hemorheology and the function of blood coagulation.关键词
水蛭/脉血康/血液流变学/凝血时间/凝血因子/大鼠Key words
hirudo/maixuekang/hemorheology/coagulation time/coagulation factor/rat分类
医药卫生引用本文复制引用
苏斌,王志斌,宋程程,郭玉东,高阳,王碧松,金家金..水蛭、脉血康对急性血瘀模型大鼠血液流变学及凝血功能的影响[J].中医学报,2014,(6):766-768,3.基金项目
国家药典委员会课题 （）
